TY - JOUR
T1 - Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus
AU - Spindler, Volker
AU - Eming, Rüdiger
AU - Schmidt, Enno
AU - Amagai, Masayuki
AU - Grando, Sergei
AU - Jonkman, Marcel F.
AU - Kowalczyk, Andrew P.
AU - Müller, Eliane J.
AU - Payne, Aimee S.
AU - Pincelli, Carlo
AU - Sinha, Animesh A.
AU - Sprecher, Eli
AU - Zillikens, Detlef
AU - Hertl, Michael
AU - Waschke, Jens
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.
AB - The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.
UR - http://www.scopus.com/inward/record.url?scp=85039948470&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2017.06.022
DO - 10.1016/j.jid.2017.06.022
M3 - Scientific review articles
AN - SCOPUS:85039948470
SN - 0022-202X
VL - 138
SP - 32
EP - 37
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -