Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

Rebecca Oelkrug; Christin Krause; Beate Herrmann; Julia Resch; Sogol Gachkar; Alexander T. El Gammal; Stefan Wolter; Oliver Mann; Henrik Oster; Henriette Kirchner; Jens Mittag

doi:10.1016/j.celrep.2020.108351

Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

Rebecca Oelkrug, Christin Krause, Beate Herrmann, Julia Resch, Sogol Gachkar, Alexander T. El Gammal, Stefan Wolter, Oliver Mann, Henrik Oster, Henriette Kirchner, Jens Mittag^*

^*Corresponding author for this work

University Hospital Hamburg-Eppendorf

14 Citations (Scopus)

Abstract

It is commonly assumed that metabolic adaptations to cold climates are a result of transgenerational selection. Oelkrug et al. show that minor changes in gestational temperature alter male offspring's metabolism. Specifically, maternal brown fat activation reduces their lean mass and glucose tolerance, which is reversible by exercise.

Original language	English
Article number	108351
Journal	Cell Reports
Volume	33
Issue number	5
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2020.108351
Publication status	Published - 03.11.2020

Funding

We thank Frank van Breukelen and Martin Jastroch for constructive criticism and the staff of the GTH for technical assistance. This work was supported by the Deutsche Forschungsgemeinschaft ( MI1242/2-2 and 3-2 Heisenberg Program and Mi1242/6-1 SPP1629 Thyroid TransAct to J.M., OE723/2-1 to R.O., Emmy Noether Program KI1887/2-2 to H.K.) and the Medical Faculty of the University of Lübeck ( J14-2018 ) to R.O. B.H. and S.G. are students of the GRK1957 “Adipocyte-Brain-Crosstalk.”

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

2.22-17 Endocrinology, Diabetology, Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.celrep.2020.108351

Cite this

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title = "Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring",

abstract = "It is commonly assumed that metabolic adaptations to cold climates are a result of transgenerational selection. Oelkrug et al. show that minor changes in gestational temperature alter male offspring's metabolism. Specifically, maternal brown fat activation reduces their lean mass and glucose tolerance, which is reversible by exercise.",

author = "Rebecca Oelkrug and Christin Krause and Beate Herrmann and Julia Resch and Sogol Gachkar and \{El Gammal\}, \{Alexander T.\} and Stefan Wolter and Oliver Mann and Henrik Oster and Henriette Kirchner and Jens Mittag",

note = "Funding Information: We thank Frank van Breukelen and Martin Jastroch for constructive criticism and the staff of the GTH for technical assistance. This work was supported by the Deutsche Forschungsgemeinschaft ( MI1242/2-2 and 3-2 Heisenberg Program and Mi1242/6-1 SPP1629 Thyroid TransAct to J.M., OE723/2-1 to R.O., Emmy Noether Program KI1887/2-2 to H.K.) and the Medical Faculty of the University of L{\"u}beck ( J14-2018 ) to R.O. B.H. and S.G. are students of the GRK1957 “Adipocyte-Brain-Crosstalk.” Publisher Copyright: {\textcopyright} 2020 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.celrep.2020.108351",

language = "English",

volume = "33",

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T1 - Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

AU - Oelkrug, Rebecca

AU - Krause, Christin

AU - Herrmann, Beate

AU - Resch, Julia

AU - Gachkar, Sogol

AU - El Gammal, Alexander T.

AU - Wolter, Stefan

AU - Mann, Oliver

AU - Oster, Henrik

AU - Kirchner, Henriette

AU - Mittag, Jens

N1 - Funding Information: We thank Frank van Breukelen and Martin Jastroch for constructive criticism and the staff of the GTH for technical assistance. This work was supported by the Deutsche Forschungsgemeinschaft ( MI1242/2-2 and 3-2 Heisenberg Program and Mi1242/6-1 SPP1629 Thyroid TransAct to J.M., OE723/2-1 to R.O., Emmy Noether Program KI1887/2-2 to H.K.) and the Medical Faculty of the University of Lübeck ( J14-2018 ) to R.O. B.H. and S.G. are students of the GRK1957 “Adipocyte-Brain-Crosstalk.” Publisher Copyright: © 2020 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2020/11/3

Y1 - 2020/11/3

N2 - It is commonly assumed that metabolic adaptations to cold climates are a result of transgenerational selection. Oelkrug et al. show that minor changes in gestational temperature alter male offspring's metabolism. Specifically, maternal brown fat activation reduces their lean mass and glucose tolerance, which is reversible by exercise.

AB - It is commonly assumed that metabolic adaptations to cold climates are a result of transgenerational selection. Oelkrug et al. show that minor changes in gestational temperature alter male offspring's metabolism. Specifically, maternal brown fat activation reduces their lean mass and glucose tolerance, which is reversible by exercise.

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DO - 10.1016/j.celrep.2020.108351

M3 - Journal articles

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AN - SCOPUS:85095418629

SN - 2211-1247

VL - 33

JO - Cell Reports

JF - Cell Reports

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ER -

Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

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