Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

Rebecca Oelkrug, Christin Krause, Beate Herrmann, Julia Resch, Sogol Gachkar, Alexander T. El Gammal, Stefan Wolter, Oliver Mann, Henrik Oster, Henriette Kirchner, Jens Mittag*

*Corresponding author for this work

Abstract

It is commonly assumed that metabolic adaptations to cold climates are a result of transgenerational selection. Oelkrug et al. show that minor changes in gestational temperature alter male offspring's metabolism. Specifically, maternal brown fat activation reduces their lean mass and glucose tolerance, which is reversible by exercise.

Original languageEnglish
Article number108351
JournalCell Reports
Volume33
Issue number5
ISSN2211-1247
DOIs
Publication statusPublished - 03.11.2020

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism

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