Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman

Volker M Tronnier; Dirk Rasche; Veronika Thorns; Daniel Alvarez-Fischer; Thomas F Münte; Bartosz Zurowski

doi:10.1080/13554794.2018.1431678

Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman

Volker M Tronnier, Dirk Rasche, Veronika Thorns, Daniel Alvarez-Fischer, Thomas F Münte, Bartosz Zurowski

Abstract

Obese individuals share behavioral characteristics with drug/alcohol addicts as well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used successfully in these disorders, thus warranting an evaluation in obesity. A woman with treatment-resistant depression as well as severe obesity was selected for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the primary and obesity being the secondary target of treatment. Compared to earlier bariatric surgery, the patient showed accelerated weight loss after DBS. Also, depression was significantly reduced. The current case suggests that DBS of the NAcc warrants further evaluation in patients unresponsive to other treatments.

Original language	English
Journal	Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology
Volume	24
Issue number	1
Pages (from-to)	49-53
Number of pages	5
ISSN	1355-4794
DOIs	https://doi.org/10.1080/13554794.2018.1431678
Publication status	Published - 02.2018

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10.1080/13554794.2018.1431678

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abstract = "Obese individuals share behavioral characteristics with drug/alcohol addicts as well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used successfully in these disorders, thus warranting an evaluation in obesity. A woman with treatment-resistant depression as well as severe obesity was selected for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the primary and obesity being the secondary target of treatment. Compared to earlier bariatric surgery, the patient showed accelerated weight loss after DBS. Also, depression was significantly reduced. The current case suggests that DBS of the NAcc warrants further evaluation in patients unresponsive to other treatments.",

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Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman. / Tronnier, Volker M ; Rasche, Dirk; Thorns, Veronika et al.
In: Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology, Vol. 24, No. 1, 02.2018, p. 49-53.

Research output: Journal Articles › Journal articles › Research › peer-review

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T1 - Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman

AU - Tronnier, Volker M

AU - Rasche, Dirk

AU - Thorns, Veronika

AU - Alvarez-Fischer, Daniel

AU - Münte, Thomas F

AU - Zurowski, Bartosz

PY - 2018/2

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N2 - Obese individuals share behavioral characteristics with drug/alcohol addicts as well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used successfully in these disorders, thus warranting an evaluation in obesity. A woman with treatment-resistant depression as well as severe obesity was selected for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the primary and obesity being the secondary target of treatment. Compared to earlier bariatric surgery, the patient showed accelerated weight loss after DBS. Also, depression was significantly reduced. The current case suggests that DBS of the NAcc warrants further evaluation in patients unresponsive to other treatments.

AB - Obese individuals share behavioral characteristics with drug/alcohol addicts as well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used successfully in these disorders, thus warranting an evaluation in obesity. A woman with treatment-resistant depression as well as severe obesity was selected for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the primary and obesity being the secondary target of treatment. Compared to earlier bariatric surgery, the patient showed accelerated weight loss after DBS. Also, depression was significantly reduced. The current case suggests that DBS of the NAcc warrants further evaluation in patients unresponsive to other treatments.

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DO - 10.1080/13554794.2018.1431678

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JO - Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology

JF - Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology

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ER -

Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman

Abstract

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