Massive creatine kinase elevations with quetiapine: Report of two cases - A case report

J. P. Klein; U. Fiedler; H. Appel; A. Quante; Maria C. Jockers-Scherübl

doi:10.1055/s-2006-931478

Massive creatine kinase elevations with quetiapine: Report of two cases - A case report

J. P. Klein, U. Fiedler, H. Appel, A. Quante, Maria C. Jockers-Scherübl^*

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

Charite - Universitatsmedizin Berlin

15 Citations (Scopus)

Abstract

Massive elevations of serum creatine kinase (CK) can occur in a significant number of patients treated with neuroleptics in the absence of neuroleptic malignant syndrome (NMS). We report two cases of CK-elevations associated with quetiapine treatment, which disappeared after drug discontinuation. To our knowledge, case number one is the first case of quetiapine-induced CK elevation in a neuroleptic-naïve patient. We thus suggest CK assessment when myalgia occurs with neuroleptic treatment.

Original language	English
Journal	Pharmacopsychiatry
Volume	39
Issue number	1
Pages (from-to)	39-40
Number of pages	2
ISSN	0176-3679
DOIs	https://doi.org/10.1055/s-2006-931478
Publication status	Published - 01.2006

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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abstract = "Massive elevations of serum creatine kinase (CK) can occur in a significant number of patients treated with neuroleptics in the absence of neuroleptic malignant syndrome (NMS). We report two cases of CK-elevations associated with quetiapine treatment, which disappeared after drug discontinuation. To our knowledge, case number one is the first case of quetiapine-induced CK elevation in a neuroleptic-na{\"i}ve patient. We thus suggest CK assessment when myalgia occurs with neuroleptic treatment.",

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AB - Massive elevations of serum creatine kinase (CK) can occur in a significant number of patients treated with neuroleptics in the absence of neuroleptic malignant syndrome (NMS). We report two cases of CK-elevations associated with quetiapine treatment, which disappeared after drug discontinuation. To our knowledge, case number one is the first case of quetiapine-induced CK elevation in a neuroleptic-naïve patient. We thus suggest CK assessment when myalgia occurs with neuroleptic treatment.

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Massive creatine kinase elevations with quetiapine: Report of two cases - A case report

Abstract

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