MarginProbe® - Final results of the German post-market study in breast conserving surgery of ductal carcinoma in situ

Marc Thill; Christine Dittmer; Kristin Baumann; Kay Friedrichs; Jens Uwe Blohmer

doi:10.1016/j.breast.2013.11.002

MarginProbe^® - Final results of the German post-market study in breast conserving surgery of ductal carcinoma in situ

Marc Thill^*, Christine Dittmer, Kristin Baumann, Kay Friedrichs, Jens Uwe Blohmer

^*Corresponding author for this work

Clinic of Gynecology and Obstetrics

23 Citations (Scopus)

Abstract

The goal in breast conserving surgery (BCS) of ductal carcinoma in situ (DCIS) is removal of the tumor with a clear surgical margin. However, re-excision rates are regrettably high. To date, there are no adequate procedures for intraoperative margin assessment of DCIS. A multicenter, single arm study was conducted to evaluate the benefit of a novel device (MarginProbe^®) in intraoperative margin assessment during BCS of DCIS, the associated reduction of re-excisions and the cosmetic outcome of the treated patients. We present results of 42 patients enrolled in 3 German institutions. The device was used as an adjunctive tool to standard of care. The device use was associated with a reduction in re-excision rates by 56%, from 39% to 17% (p=0.018).

Original language	English
Journal	Breast
Volume	23
Issue number	1
Pages (from-to)	94-96
Number of pages	3
ISSN	0960-9776
DOIs	https://doi.org/10.1016/j.breast.2013.11.002
Publication status	Published - 02.2014

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10.1016/j.breast.2013.11.002

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title = "MarginProbe{\textregistered} - Final results of the German post-market study in breast conserving surgery of ductal carcinoma in situ",

abstract = "The goal in breast conserving surgery (BCS) of ductal carcinoma in situ (DCIS) is removal of the tumor with a clear surgical margin. However, re-excision rates are regrettably high. To date, there are no adequate procedures for intraoperative margin assessment of DCIS. A multicenter, single arm study was conducted to evaluate the benefit of a novel device (MarginProbe{\textregistered}) in intraoperative margin assessment during BCS of DCIS, the associated reduction of re-excisions and the cosmetic outcome of the treated patients. We present results of 42 patients enrolled in 3 German institutions. The device was used as an adjunctive tool to standard of care. The device use was associated with a reduction in re-excision rates by 56%, from 39% to 17% (p=0.018).",

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AU - Thill, Marc

AU - Dittmer, Christine

AU - Baumann, Kristin

AU - Friedrichs, Kay

AU - Blohmer, Jens Uwe

PY - 2014/2

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AB - The goal in breast conserving surgery (BCS) of ductal carcinoma in situ (DCIS) is removal of the tumor with a clear surgical margin. However, re-excision rates are regrettably high. To date, there are no adequate procedures for intraoperative margin assessment of DCIS. A multicenter, single arm study was conducted to evaluate the benefit of a novel device (MarginProbe®) in intraoperative margin assessment during BCS of DCIS, the associated reduction of re-excisions and the cosmetic outcome of the treated patients. We present results of 42 patients enrolled in 3 German institutions. The device was used as an adjunctive tool to standard of care. The device use was associated with a reduction in re-excision rates by 56%, from 39% to 17% (p=0.018).

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MarginProbe^® - Final results of the German post-market study in breast conserving surgery of ductal carcinoma in situ

Abstract

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