Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

Inke R. König; Johannes Schumacher; Per Hoffmann; André Kleensang; Kerstin U. Ludwig; Tiemo Grimm; Nina Neuhoff; Maike Preis; Darina Roeske; Andreas Warnke; Peter Propping; Helmut Remschmidt; Markus M. Nöthen; Andreas Ziegler; Bertram Müller-Myhsok; Gerd Schulte-Körne

doi:10.1002/ajmg.b.31135

Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

Inke R. König, Johannes Schumacher, Per Hoffmann, André Kleensang, Kerstin U. Ludwig, Tiemo Grimm, Nina Neuhoff, Maike Preis, Darina Roeske, Andreas Warnke, Peter Propping, Helmut Remschmidt, Markus M. Nöthen, Andreas Ziegler, Bertram Müller-Myhsok, Gerd Schulte-Körne^*

^*Corresponding author for this work

31 Citations (Scopus)

Abstract

In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P=1.00×10^-7) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. © 2010 Wiley-Liss, Inc.

Original language	English
Journal	American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume	156
Issue number	1
Pages (from-to)	36-43
Number of pages	8
ISSN	1552-4841
DOIs	https://doi.org/10.1002/ajmg.b.31135
Publication status	Published - 01.2011

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König, I. R., Schumacher, J., Hoffmann, P., Kleensang, A., Ludwig, K. U., Grimm, T., Neuhoff, N., Preis, M., Roeske, D., Warnke, A., Propping, P., Remschmidt, H., Nöthen, M. M., Ziegler, A., Müller-Myhsok, B., & Schulte-Körne, G. (2011). Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 156(1), 36-43. https://doi.org/10.1002/ajmg.b.31135

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title = "Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21",

abstract = "In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P=1.00×10-7) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. {\textcopyright} 2010 Wiley-Liss, Inc.",

author = "K{\"o}nig, \{Inke R.\} and Johannes Schumacher and Per Hoffmann and Andr{\'e} Kleensang and Ludwig, \{Kerstin U.\} and Tiemo Grimm and Nina Neuhoff and Maike Preis and Darina Roeske and Andreas Warnke and Peter Propping and Helmut Remschmidt and N{\"o}then, \{Markus M.\} and Andreas Ziegler and Bertram M{\"u}ller-Myhsok and Gerd Schulte-K{\"o}rne",

year = "2011",

month = jan,

doi = "10.1002/ajmg.b.31135",

language = "English",

volume = "156",

pages = "36--43",

journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",

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König, IR, Schumacher, J, Hoffmann, P, Kleensang, A, Ludwig, KU, Grimm, T, Neuhoff, N, Preis, M, Roeske, D, Warnke, A, Propping, P, Remschmidt, H, Nöthen, MM, Ziegler, A, Müller-Myhsok, B & Schulte-Körne, G 2011, 'Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21', American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 156, no. 1, pp. 36-43. https://doi.org/10.1002/ajmg.b.31135

Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. / König, Inke R.; Schumacher, Johannes; Hoffmann, Per et al.
In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 156, No. 1, 01.2011, p. 36-43.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

AU - König, Inke R.

AU - Schumacher, Johannes

AU - Hoffmann, Per

AU - Kleensang, André

AU - Ludwig, Kerstin U.

AU - Grimm, Tiemo

AU - Neuhoff, Nina

AU - Preis, Maike

AU - Roeske, Darina

AU - Warnke, Andreas

AU - Propping, Peter

AU - Remschmidt, Helmut

AU - Nöthen, Markus M.

AU - Ziegler, Andreas

AU - Müller-Myhsok, Bertram

AU - Schulte-Körne, Gerd

PY - 2011/1

Y1 - 2011/1

N2 - In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P=1.00×10-7) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. © 2010 Wiley-Liss, Inc.

AB - In a genome-wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single-proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome-wide significant LOD score of 5.87 (P=1.00×10-7) and the implicated 6p-risk region spans around 10Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. © 2010 Wiley-Liss, Inc.

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DO - 10.1002/ajmg.b.31135

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C2 - 21184582

AN - SCOPUS:79953661892

SN - 1552-4841

VL - 156

SP - 36

EP - 43

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

IS - 1

ER -

Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21

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