Management of Very Early-onset Fetal Growth Restriction: Results from 92 Consecutive Cases

Friederike Hoellen; Annika Beckmann; Constanze Banz-Jansen; Jan Weichert; Achim Rody; Michael K Bohlmann

Management of Very Early-onset Fetal Growth Restriction: Results from 92 Consecutive Cases

Friederike Hoellen, Annika Beckmann, Constanze Banz-Jansen, Jan Weichert, Achim Rody, Michael K Bohlmann

Department of Gynecology and Obstetrics

Abstract

AIM: To evaluate management of early-onset intrauterine growth restriction (IUGR) and to define outcome according to obstetric setting.

PATIENTS AND METHODS: During an 11-year period (2000-2011), data of patients presenting with IUGR and preterm delivery of less than 30 weeks of gestation at a tertiary perinatal center were retrospectively reviewed.

RESULTS: A total of 92 pregnancies were investigated. Delivery was indicated for fetal reasons in 38 out of 92 patients. Sixteen children of our cohort died within one year post partum, out of which eight had suffered from severe early-onset IUGR causing iatrogenic preterm delivery. Concerning the fetal outcome, gestational age at delivery and antenatal exposure to corticosteroids were found to be crucial.

CONCLUSION: In some cases, respiratory distress syndrome prophylaxis and a "wait and see" approach to management in favor of a prolongation of the pregnancy might be favorable. Randomized prospective trials in early-onset IUGR with threatened preterm deliveries are needed in order to define guidelines for an individually tailored management of early-onset preterm infants.

Original language	English
Journal	In vivo (Athens, Greece)
Volume	30
Issue number	2
Pages (from-to)	123-31
Number of pages	9
ISSN	0258-851X
Publication status	Published - 26.02.2016

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title = "Management of Very Early-onset Fetal Growth Restriction: Results from 92 Consecutive Cases",

abstract = "AIM: To evaluate management of early-onset intrauterine growth restriction (IUGR) and to define outcome according to obstetric setting.PATIENTS AND METHODS: During an 11-year period (2000-2011), data of patients presenting with IUGR and preterm delivery of less than 30 weeks of gestation at a tertiary perinatal center were retrospectively reviewed.RESULTS: A total of 92 pregnancies were investigated. Delivery was indicated for fetal reasons in 38 out of 92 patients. Sixteen children of our cohort died within one year post partum, out of which eight had suffered from severe early-onset IUGR causing iatrogenic preterm delivery. Concerning the fetal outcome, gestational age at delivery and antenatal exposure to corticosteroids were found to be crucial.CONCLUSION: In some cases, respiratory distress syndrome prophylaxis and a {"}wait and see{"} approach to management in favor of a prolongation of the pregnancy might be favorable. Randomized prospective trials in early-onset IUGR with threatened preterm deliveries are needed in order to define guidelines for an individually tailored management of early-onset preterm infants.",

author = "Friederike Hoellen and Annika Beckmann and Constanze Banz-Jansen and Jan Weichert and Achim Rody and Bohlmann, \{Michael K\}",

year = "2016",

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day = "26",

language = "English",

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pages = "123--31",

journal = "In vivo (Athens, Greece)",

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publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Management of Very Early-onset Fetal Growth Restriction

T2 - Results from 92 Consecutive Cases

AU - Hoellen, Friederike

AU - Beckmann, Annika

AU - Banz-Jansen, Constanze

AU - Weichert, Jan

AU - Rody, Achim

AU - Bohlmann, Michael K

PY - 2016/2/26

Y1 - 2016/2/26

N2 - AIM: To evaluate management of early-onset intrauterine growth restriction (IUGR) and to define outcome according to obstetric setting.PATIENTS AND METHODS: During an 11-year period (2000-2011), data of patients presenting with IUGR and preterm delivery of less than 30 weeks of gestation at a tertiary perinatal center were retrospectively reviewed.RESULTS: A total of 92 pregnancies were investigated. Delivery was indicated for fetal reasons in 38 out of 92 patients. Sixteen children of our cohort died within one year post partum, out of which eight had suffered from severe early-onset IUGR causing iatrogenic preterm delivery. Concerning the fetal outcome, gestational age at delivery and antenatal exposure to corticosteroids were found to be crucial.CONCLUSION: In some cases, respiratory distress syndrome prophylaxis and a "wait and see" approach to management in favor of a prolongation of the pregnancy might be favorable. Randomized prospective trials in early-onset IUGR with threatened preterm deliveries are needed in order to define guidelines for an individually tailored management of early-onset preterm infants.

AB - AIM: To evaluate management of early-onset intrauterine growth restriction (IUGR) and to define outcome according to obstetric setting.PATIENTS AND METHODS: During an 11-year period (2000-2011), data of patients presenting with IUGR and preterm delivery of less than 30 weeks of gestation at a tertiary perinatal center were retrospectively reviewed.RESULTS: A total of 92 pregnancies were investigated. Delivery was indicated for fetal reasons in 38 out of 92 patients. Sixteen children of our cohort died within one year post partum, out of which eight had suffered from severe early-onset IUGR causing iatrogenic preterm delivery. Concerning the fetal outcome, gestational age at delivery and antenatal exposure to corticosteroids were found to be crucial.CONCLUSION: In some cases, respiratory distress syndrome prophylaxis and a "wait and see" approach to management in favor of a prolongation of the pregnancy might be favorable. Randomized prospective trials in early-onset IUGR with threatened preterm deliveries are needed in order to define guidelines for an individually tailored management of early-onset preterm infants.

M3 - Journal articles

C2 - 26912823

SN - 0258-851X

VL - 30

SP - 123

EP - 131

JO - In vivo (Athens, Greece)

JF - In vivo (Athens, Greece)

IS - 2

ER -

Management of Very Early-onset Fetal Growth Restriction: Results from 92 Consecutive Cases

Abstract

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