Major depression and impaired glucose tolerance

B. Weber*, U. Schweiger, M. Deuschle, I. Heuser

*Corresponding author for this work
68 Citations (Scopus)


Hypercortisolism is a frequent endocrine sign in major depression and cortisol is a well-known anti-insulinergic hormone. Impaired oral glucose tolerance has already been described in major depression. However, thus far no information is available on spontaneous, circadian insulin secretion in patients. We studied 26 depressed inpatients along with 33 age- and sex-matched controls. Blood samples were collected at 30-minute intervals over a period of 26 hours (h) for estimation of cortisol, insulin and glucose. No differences in 24 h mean-insulin and glucose concentrations were detectable despite significantly reduced caloric consumption in patients. At the second morning a strictly standardized test meal of 2125 kjoule was given. Insulin and glucose responses to the test meal were significantly increased in hypercortisolemic patients compared to controls. Hence, patients with major depression have an impaired insulin sensitivity.

Original languageEnglish
JournalExperimental and Clinical Endocrinology and Diabetes
Issue number3
Pages (from-to)187-190
Number of pages4
Publication statusPublished - 2000

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


Dive into the research topics of 'Major depression and impaired glucose tolerance'. Together they form a unique fingerprint.

Cite this