In recent years, research on magnetic nanoparticles used for medical imaging has been enormously stimulated by the invention of a new imaging principle. By this invention based on dynamically changing magnetic fields, the spatial distribution of SPIONs, i.e. super-paramagnetic iron oxide nanoparticles, can directly be visualized. The method named magnetic particle imaging (MPI) allows for acquiring three-dimensional functional images with high sensitivity in real-time. Therefore, this contribution focuses on the production of appropriate nanoparticles. Besides mechanical top-down strategies, the precipitation based bottom-up procedures have proven to be the method of choice if a high yield of the magnetic fluid is required. However, a key issue of nanoparticle production for MPI is quality control. The method of magnetic particle spectroscopy is especially adapted to this task because it is based on the imaging principle. Finally, in addition to the techniques of synthesis and analyses of magnetic nanoparticles, medical application scenarios will be described.
|Translated title of the contribution||From synthesis to clinical application: Magnetic nanoparticles|
|Journal||Chemie in Unserer Zeit|
|Number of pages||8|
|Publication status||Published - 02.2012|
Research Areas and Centers
- Academic Focus: Biomedical Engineering