Magnetic Particle Imaging

Jörn Borgert, Bernhard Gleich, Thorsten M. Buzug


Magnetic particle imaging (MPI) is a quantitative imaging method that uses the nonlinear re-magnetization behavior of ferromagnetic nanoparticles to determine their local concentration. Superparamagnetic iron oxide (SPIO) particles represent such suitable nanoparticles. SPIOs are readily available as clinically approved contrast agents for liver examinations in magnetic resonance imaging (MRI), and usually administered into the bloodstream via intravenous injection. Starting from a brief overview of the history of the discovery and ongoing research on MPI in Sect. 24.2, Sect. 24.3 introduces the technical concepts of MPI. Section 24. 4 will explain how to get to actual images, once data has been acquired. Section 24.5 describes alternative system designs next to traditional, symmetric geometries commonly used for medical imaging devices, and other uses of magnetic particle imaging technology, like spectroscopy. A possible combination of MPI with magnetic resonance tomography (MRT) for hybrid MPI/MRT systems is introduced in Sect.24.5.3. Finally, Sect. 24.6 discusses potential applications for MPI and how it can provide clinical benefits, covering cardiovascular applications in Sect.24.6.1, oncology applications in Sect.24.6.2, cell labeling/tracking in Sect. 24.6.3, and concluding with applications that require new, modified tracer materials in Sect. 24.6.4.
Original languageEnglish
Title of host publicationSpringer Handbook of Medical Technology
EditorsRüdiger Kramme, Klaus-Peter Hoffmann, Robert S. Pozos
Number of pages16
Place of PublicationBerlin, Heidelberg
PublisherSpringer Berlin Heidelberg
Publication date2011
ISBN (Print)978-3-540-74657-7
ISBN (Electronic)978-3-540-74658-4
Publication statusPublished - 2011


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