Mütterliche Thrombophilien: Bedeutung für Kinderwunschbehandlung und Frühschwangerschaft

The association between maternal thrombophilia and an increased risk of pregnancy -associated thromboembolic events is well established. According to specific thrombophilic disorders, risk-adapted strategies for prevention and treatment are mandatory. Anticoagulation treatment is usually to started after pregnancy has been detectedion. Further consequences of maternal thrombophilic disorders may include complications such as recurrent miscarriage, intrauterine growth restriction reduction and preeclampsia. A sScreening for thrombophilic disorders is advisable for all patients with a positive personal or family history of thromboembolic diseases or recurrent miscarriages, but not generally for all women who desire to become pregnant. Prophylactic anticoagulation is not indicated to improve pregnancy rates in patients undergoing assisted reproduction, whereas current data areis inconsistent regarding whether heparin is beneficial in patients with a history of recurrent miscarriages after an antiphospholipid syndrome hasd been excluded.