Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations

Kamil Sedlacek; Katharina Neureuther; Jakob C. Mueller; Klaus Stark; Marcus Fischer; Andrea Baessler; Wibke Reinhard; Ulrich Broeckel; Wolfgang Lieb; Jeanette Erdmann; Heribert Schunkert; Günter Riegger; Thomas Illig; Thomas Meitinger; Christian Hengstenberg

doi:10.1007/s00109-007-0211-4

Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations

Kamil Sedlacek, Katharina Neureuther, Jakob C. Mueller, Klaus Stark, Marcus Fischer, Andrea Baessler, Wibke Reinhard, Ulrich Broeckel, Wolfgang Lieb, Jeanette Erdmann, Heribert Schunkert, Günter Riegger, Thomas Illig, Thomas Meitinger, Christian Hengstenberg^*

^*Corresponding author for this work

Department of Internal Medicine II

22 Citations (Scopus)

Abstract

Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-α (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.

Original language	English
Journal	Journal of Molecular Medicine
Volume	85
Issue number	9
Pages (from-to)	997-1004
Number of pages	8
ISSN	0946-2716
DOIs	https://doi.org/10.1007/s00109-007-0211-4
Publication status	Published - 01.09.2007

Funding

CHRISTIAN HENGSTENBERG he received his M.D. from the University of Würzburg. After 2 years of clinical training, he received a research fellowship grant and spent 2 years at Ketty Schwartz’s lab at the INSERM in Paris, France. On his return, he pursued his clinical training in internal medicine and cardiology. He is currently Professor of Car diology at the Regensburg Uni versity School of Medicine. His research interests include genetics of cardiovascular diseases. Acknowledgment We appreciate the invaluable contribution of participants of the German MI Family Study, KORA Register and WHO MONICA Survey. We gratefully acknowledge the excellent technical assistance of Martina Köhler, Josef Simon, and Michaela Vöstner. This study was supported by the Deutsche Forschungsgemeinschaft (He1921/ 9-1, Schu672/14-1), the National Genome Network (01GS0418 to Drs Schunkert, Erdmann, and Hengstenberg), The Ernst-and Berta-Grimmke-Stiftung (Drs. Hengstenberg and Schunkert), the Wilhelm-Vaillant-Stiftung (Drs. Hengstenberg, Schunkert), the Deutsche Stiftung für Herzforschung (Drs. Hengstenberg and Schunkert). The KORA group consists of H.E. Wichmann (speaker), H. Löwel, C. Meisinger, T. Illig, R. Holle, J. John and their coworkers who are responsible for the design and conduct of the KORA studies. The MONICA Augsburg Study was initiated and conducted by Ulrich Keil and coworkers. The KORA research platform (KORA: Cooperative Research in the Region of Augsburg) and the MONICA Augsburg studies (Monitoring trends and determinants on cardiovascular diseases) were initiated and financed by the GSF-National Research Centre for Environment and Health, which is funded by the German Federal Ministry of Education, Science, Research and Technology and by the State of Bavaria.

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10.1007/s00109-007-0211-4

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Sedlacek, K., Neureuther, K., Mueller, J. C., Stark, K., Fischer, M., Baessler, A., Reinhard, W., Broeckel, U., Lieb, W., Erdmann, J., Schunkert, H., Riegger, G., Illig, T., Meitinger, T., & Hengstenberg, C. (2007). Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations. Journal of Molecular Medicine, 85(9), 997-1004. https://doi.org/10.1007/s00109-007-0211-4

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title = "Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations",

abstract = "Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-α (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.",

author = "Kamil Sedlacek and Katharina Neureuther and Mueller, \{Jakob C.\} and Klaus Stark and Marcus Fischer and Andrea Baessler and Wibke Reinhard and Ulrich Broeckel and Wolfgang Lieb and Jeanette Erdmann and Heribert Schunkert and G{\"u}nter Riegger and Thomas Illig and Thomas Meitinger and Christian Hengstenberg",

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Sedlacek, K, Neureuther, K, Mueller, JC, Stark, K, Fischer, M, Baessler, A, Reinhard, W, Broeckel, U, Lieb, W, Erdmann, J, Schunkert, H, Riegger, G, Illig, T, Meitinger, T & Hengstenberg, C 2007, 'Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations', Journal of Molecular Medicine, vol. 85, no. 9, pp. 997-1004. https://doi.org/10.1007/s00109-007-0211-4

TY - JOUR

T1 - Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations

AU - Sedlacek, Kamil

AU - Neureuther, Katharina

AU - Mueller, Jakob C.

AU - Stark, Klaus

AU - Fischer, Marcus

AU - Baessler, Andrea

AU - Reinhard, Wibke

AU - Broeckel, Ulrich

AU - Lieb, Wolfgang

AU - Erdmann, Jeanette

AU - Schunkert, Heribert

AU - Riegger, Günter

AU - Illig, Thomas

AU - Meitinger, Thomas

AU - Hengstenberg, Christian

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-α (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.

AB - Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-α (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.

UR - https://www.scopus.com/pages/publications/34547848794

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DO - 10.1007/s00109-007-0211-4

M3 - Journal articles

C2 - 17497114

AN - SCOPUS:34547848794

SN - 0946-2716

VL - 85

SP - 997

EP - 1004

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

IS - 9

ER -

Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations

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