TY - JOUR
T1 - Lymphotoxin-α and galectin-2 SNPs are not associated with myocardial infarction in two different German populations
AU - Sedlacek, Kamil
AU - Neureuther, Katharina
AU - Mueller, Jakob C.
AU - Stark, Klaus
AU - Fischer, Marcus
AU - Baessler, Andrea
AU - Reinhard, Wibke
AU - Broeckel, Ulrich
AU - Lieb, Wolfgang
AU - Erdmann, Jeanette
AU - Schunkert, Heribert
AU - Riegger, Günter
AU - Illig, Thomas
AU - Meitinger, Thomas
AU - Hengstenberg, Christian
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-α (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.
AB - Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-α (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n=1214). Controls were unrelated disease-free participants of the study (n=1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n=607). The control group consisted of participants of the WHO MONICA survey in Germany (n=1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.
UR - http://www.scopus.com/inward/record.url?scp=34547848794&partnerID=8YFLogxK
U2 - 10.1007/s00109-007-0211-4
DO - 10.1007/s00109-007-0211-4
M3 - Journal articles
C2 - 17497114
AN - SCOPUS:34547848794
SN - 0946-2716
VL - 85
SP - 997
EP - 1004
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
IS - 9
ER -
