Lymphomatoide Granulomatose - Remissionsinduktion mit Interferon-α(2b)

Translated title of the contribution: Induction of remission of lymphomatoid granulomatosis with interferon α(2b)

C. Richter*, A. Schnabel, K. M. Müller, M. Reuter, P. Schuster, W. L. Gross

*Corresponding author for this work
15 Citations (Scopus)


History and admission findings: A 72-year-old woman was admitted to hospital because of nonproductive cough, acrodistal sensorimotor axonal polyneuropathy, fatigue and 10 kg weight loss over the preceding 9 months. Investigations: Chest radiogram showed multiple round foci in both lungs. No organs other than the lungs and the peripheral nervous system were affected. Open lung biopsy revealed a pleomorphic angioinvasive lymphocytic infiltrations. Diagnosis, treatment and course: The findings indicated lymphomatoid granulomatosis (LG). Wegener granulomatosis was excluded on the basis of the clinical, serological and histopathological findings. Treatment with α-interferon (IFN-α) produced complete remission within 4 months. Interruption of treatment immediately resulted in a recurrence. Conclusion: Together with previously reported cases this patient's response to IFN-α suggests that IFN-α is a less toxic alternative to cyclophosphamide and corticosteroid administration in the early stages of LG.

Translated title of the contributionInduction of remission of lymphomatoid granulomatosis with interferon α(2b)
Original languageGerman
JournalDeutsche Medizinische Wochenschrift
Issue number37
Pages (from-to)1106-1110
Number of pages5
Publication statusPublished - 1997

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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