Projects per year
There is an abundance of data dealing with recirculation of T cells in the rats, but relatively little is known about the traffic of B cells. The adhesion molecules expressed on the surface membrane are of great significance for recirculation of lymphocytes. However, very little is known about the expression of various adhesion molecules on B-cell subsets. Here we show that in normal rats various adhesion molecules are differentially expressed on B-cell subsets and that the level of their expression changes after the entry of B lymphocytes from the blood into the lymphoid tissues. In splenectomized rats, the surface expression of LFA-1 and ICAM-1 is selectively reduced on B-cell subsets in blood and lymph node, which is accompanied by a selective increase in the number of all B-cell subsets in the blood. The decreased surface expression of adhesion molecules results in faster migration of B lymphocytes through lymph nodes with subsequent accumulation of these cells in the blood.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
FingerprintDive into the research topics of 'Lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 expression on B-cell subsets and the effects of splenectomy - Experimental studies'. Together they form a unique fingerprint.
- 1 Finished
Regulation of the expression of surface molecules on B and T lymphocytes during their migration through lymphatic tissues
01.01.02 → 31.12.11
Project: DFG Projects › DFG Individual Projects