Low lumbar bone mineral density in patients with major depression

Ulrich Schweiger; Michael Deuschle; Andreas Körner; Claas Hinrich Lammers; Jürgen Schmider; Ulrike Gotthardt; Florian Holsboer; Isabella Heuser

doi:10.1176/ajp.151.11.1691

Low lumbar bone mineral density in patients with major depression

Ulrich Schweiger^*, Michael Deuschle, Andreas Körner, Claas Hinrich Lammers, Jürgen Schmider, Ulrike Gotthardt, Florian Holsboer, Isabella Heuser

^*Corresponding author for this work

Department of Psychiatry, Psychosomatics and Psychotherapie

Max Planck Institute

159 Citations (Scopus)

Abstract

Major depression is associated with hypercorticoidism, a risk factor for osteoporosis. However, it is unknown whether depressive disorders are associated with alterations in bone mineral density. The authors measured the density of trabecular bone from the first to the third lumbar vertebra by quantitative computerized tomography in 80 depressed inpatients older than 40 years and in 57 healthy comparison subjects. An analysis of covariance model with age as a covariate showed a significant effect of diagnosis on the dependent variable spinal bone mineral density: depressed patients had lower values. Other factors could not explain the finding. The authors conclude that major depression is a significant risk factor for osteoporosis.

Original language	English
Journal	American Journal of Psychiatry
Volume	151
Issue number	11
Pages (from-to)	1691-1693
Number of pages	3
ISSN	0002-953X
DOIs	https://doi.org/10.1176/ajp.151.11.1691
Publication status	Published - 11.1994

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1176/ajp.151.11.1691

Cite this

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title = "Low lumbar bone mineral density in patients with major depression",

abstract = "Major depression is associated with hypercorticoidism, a risk factor for osteoporosis. However, it is unknown whether depressive disorders are associated with alterations in bone mineral density. The authors measured the density of trabecular bone from the first to the third lumbar vertebra by quantitative computerized tomography in 80 depressed inpatients older than 40 years and in 57 healthy comparison subjects. An analysis of covariance model with age as a covariate showed a significant effect of diagnosis on the dependent variable spinal bone mineral density: depressed patients had lower values. Other factors could not explain the finding. The authors conclude that major depression is a significant risk factor for osteoporosis.",

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T1 - Low lumbar bone mineral density in patients with major depression

AU - Schweiger, Ulrich

AU - Deuschle, Michael

AU - Körner, Andreas

AU - Lammers, Claas Hinrich

AU - Schmider, Jürgen

AU - Gotthardt, Ulrike

AU - Holsboer, Florian

AU - Heuser, Isabella

PY - 1994/11

Y1 - 1994/11

N2 - Major depression is associated with hypercorticoidism, a risk factor for osteoporosis. However, it is unknown whether depressive disorders are associated with alterations in bone mineral density. The authors measured the density of trabecular bone from the first to the third lumbar vertebra by quantitative computerized tomography in 80 depressed inpatients older than 40 years and in 57 healthy comparison subjects. An analysis of covariance model with age as a covariate showed a significant effect of diagnosis on the dependent variable spinal bone mineral density: depressed patients had lower values. Other factors could not explain the finding. The authors conclude that major depression is a significant risk factor for osteoporosis.

AB - Major depression is associated with hypercorticoidism, a risk factor for osteoporosis. However, it is unknown whether depressive disorders are associated with alterations in bone mineral density. The authors measured the density of trabecular bone from the first to the third lumbar vertebra by quantitative computerized tomography in 80 depressed inpatients older than 40 years and in 57 healthy comparison subjects. An analysis of covariance model with age as a covariate showed a significant effect of diagnosis on the dependent variable spinal bone mineral density: depressed patients had lower values. Other factors could not explain the finding. The authors conclude that major depression is a significant risk factor for osteoporosis.

UR - https://www.scopus.com/pages/publications/0027960759

U2 - 10.1176/ajp.151.11.1691

DO - 10.1176/ajp.151.11.1691

M3 - Journal articles

C2 - 7943462

AN - SCOPUS:0027960759

SN - 0002-953X

VL - 151

SP - 1691

EP - 1693

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 11

ER -

Low lumbar bone mineral density in patients with major depression

Abstract

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