TY - JOUR
T1 - Low lumbar bone mineral density in patients with major depression
AU - Schweiger, Ulrich
AU - Deuschle, Michael
AU - Körner, Andreas
AU - Lammers, Claas Hinrich
AU - Schmider, Jürgen
AU - Gotthardt, Ulrike
AU - Holsboer, Florian
AU - Heuser, Isabella
PY - 1994/11
Y1 - 1994/11
N2 - Major depression is associated with hypercorticoidism, a risk factor for osteoporosis. However, it is unknown whether depressive disorders are associated with alterations in bone mineral density. The authors measured the density of trabecular bone from the first to the third lumbar vertebra by quantitative computerized tomography in 80 depressed inpatients older than 40 years and in 57 healthy comparison subjects. An analysis of covariance model with age as a covariate showed a significant effect of diagnosis on the dependent variable spinal bone mineral density: depressed patients had lower values. Other factors could not explain the finding. The authors conclude that major depression is a significant risk factor for osteoporosis.
AB - Major depression is associated with hypercorticoidism, a risk factor for osteoporosis. However, it is unknown whether depressive disorders are associated with alterations in bone mineral density. The authors measured the density of trabecular bone from the first to the third lumbar vertebra by quantitative computerized tomography in 80 depressed inpatients older than 40 years and in 57 healthy comparison subjects. An analysis of covariance model with age as a covariate showed a significant effect of diagnosis on the dependent variable spinal bone mineral density: depressed patients had lower values. Other factors could not explain the finding. The authors conclude that major depression is a significant risk factor for osteoporosis.
UR - http://www.scopus.com/inward/record.url?scp=0027960759&partnerID=8YFLogxK
U2 - 10.1176/ajp.151.11.1691
DO - 10.1176/ajp.151.11.1691
M3 - Journal articles
C2 - 7943462
AN - SCOPUS:0027960759
SN - 0002-953X
VL - 151
SP - 1691
EP - 1693
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 11
ER -