TY - JOUR
T1 - Loss of galectin-3 expression correlates with clear cell renal carcinoma progression and reduced survival
AU - Merseburger, Axel S.
AU - Kramer, Mario W.
AU - Hennenlotter, Jörg
AU - Serth, Jürgen
AU - Kruck, Stephan
AU - Gracia, Alfredo
AU - Stenzl, Arnulf
AU - Kuczyk, Markus A.
N1 - Funding Information:
Conflict of interest statement Axel S. Merseburger was partly sponsored by a grant from MSD Sharp Dome. Mario W. Kramer was supported by a grant from the BMEP (Biomedical Science Exchange Program).
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - Objectives: Galectin-3 is a member of the glycoprotein family, actively involved in various biological interactions including cell growth, cell adhesion, cell differentiation and apoptosis. The aim of this study was to analyze the expression of galectin-3 in clear cell renal carcinoma and to assess its prognostic significance. Methods: The expression of galectin-3 was analyzed by immunohistochemistry in 149 clear cell renal carcinomas. The levels were correlated to established clinical parameters such as nuclear grade, pathological stage, lymph node, distant metastasis, and patients-survival. Results: In normal kidney tissue, the expression of galectin-3 was found to be uniformly present in the tubular epithelial cells. A decrease of antigen expression levels were significantly associated with higher T-stages (P < 0.02), unfavourable long-term prognosis in univariate Kaplan-Meier (P < 0.007) and multivariate Cox proportional hazard analyses (P < 0.04). Univariate analysis could demonstrate an association with tumor-specific death with decreased galectin-3 expression, whereas multivariate analysis failed to prove the aforementioned observation. Conclusion: Our results suggest that a loss of galectin-3 expression is involved in renal carcinogenesis.
AB - Objectives: Galectin-3 is a member of the glycoprotein family, actively involved in various biological interactions including cell growth, cell adhesion, cell differentiation and apoptosis. The aim of this study was to analyze the expression of galectin-3 in clear cell renal carcinoma and to assess its prognostic significance. Methods: The expression of galectin-3 was analyzed by immunohistochemistry in 149 clear cell renal carcinomas. The levels were correlated to established clinical parameters such as nuclear grade, pathological stage, lymph node, distant metastasis, and patients-survival. Results: In normal kidney tissue, the expression of galectin-3 was found to be uniformly present in the tubular epithelial cells. A decrease of antigen expression levels were significantly associated with higher T-stages (P < 0.02), unfavourable long-term prognosis in univariate Kaplan-Meier (P < 0.007) and multivariate Cox proportional hazard analyses (P < 0.04). Univariate analysis could demonstrate an association with tumor-specific death with decreased galectin-3 expression, whereas multivariate analysis failed to prove the aforementioned observation. Conclusion: Our results suggest that a loss of galectin-3 expression is involved in renal carcinogenesis.
UR - http://www.scopus.com/inward/record.url?scp=56449127154&partnerID=8YFLogxK
U2 - 10.1007/s00345-008-0294-8
DO - 10.1007/s00345-008-0294-8
M3 - Journal articles
C2 - 18594826
AN - SCOPUS:56449127154
SN - 0724-4983
VL - 26
SP - 637
EP - 642
JO - World Journal of Urology
JF - World Journal of Urology
IS - 6
ER -
