Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study

Julius Obergassel; Jan Leon Rieß; Sandro Jaeckle; Silke van Elferen; Moritz Nies; Niklas Schenker; Marc Daniel Lemoine; Alexander Welcker; Shinwan Kany; Laura Rottner; Djemail Ismaili; Laura Charlotte Sommerfeld; Johannes Petersen; Katharina Govorov; Lauritz Schoof; Olga Tsoy; Jan Baumbach; Simon Pecha; Tanja Zeller; Stefan Blankenberg; Larissa Fabritz; Bruno Reißmann; Feifan Ouyang; Andreas Rillig; Andreas Metzner; Paulus Kirchhof

doi:10.1093/ehjopen/oeag002

Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study

Julius Obergassel, Jan Leon Rieß, Sandro Jaeckle, Silke van Elferen, Moritz Nies, Niklas Schenker, Marc Daniel Lemoine, Alexander Welcker, Shinwan Kany, Laura Rottner, Djemail Ismaili, Laura Charlotte Sommerfeld, Johannes Petersen, Katharina Govorov, Lauritz Schoof, Olga Tsoy, Jan Baumbach, Simon Pecha, Tanja Zeller, Stefan BlankenbergLarissa Fabritz, Bruno Reißmann, Feifan Ouyang, Andreas Rillig, Andreas Metzner, Paulus Kirchhof

Institute of Cardiogenetics

2 Citations (Scopus)

Abstract

AIMS: Optimal outcomes for patients with cardiac arrhythmias can be achieved through multimodal therapy including lifestyle support, medication, and interventions. Planning of these therapy concepts requires a detailed understanding of phenotypes, responses to therapies, and outcomes.

OBJECTIVE: The prospective Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg (TRUST) combines deep phenotypic, procedural, and follow-up information in a contemporary cohort of patients with cardiac arrhythmias.

METHODS AND RESULTS: TRUST is an investigator-initiated, prospective, cohort study enrolling consecutive patients at the UHZ Hamburg. Comprehensive baseline work-up, imaging, and biobanking at baseline is combined with follow-up using a combination of in-person visits, online questionnaires, and remote rhythm-monitoring. Enrolment started in March 2021 and is ongoing. This paper describes the design and the clinical characteristics of the first 1500 enrolled patients with verified baseline datasets (562 women (37%), median age 64 (IQR 55, 74) years). Overall, 1077/1500 patients (71%) were seen for atrial fibrillation, 161/1500 (11%) for ventricular tachycardia and premature ventricular complexes, 239/1500 (16%) for supraventricular tachycardia, and 23/1500 (2%) patients for other reasons. Ablations, rhythm surgery, or invasive procedures were performed in 1363/1500 (91%) within 1 month after inclusion.

CONCLUSION: This snapshot of the first 1500 patients enrolled in TRUST illustrates current characteristics and comorbidity burden in patients undergoing arrhythmia treatment. This rich data set will provide information on treatment patterns, detailed phenotypes, and follow-up, offering insights into the natural progression and treatment responses of arrhythmias in routine care.

Original language	English
Journal	European Heart Journal Open
Volume	6
Issue number	1
Pages (from-to)	oeag002
DOIs	https://doi.org/10.1093/ehjopen/oeag002
Publication status	Published - 01.2026

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Obergassel, J., Rieß, J. L., Jaeckle, S., van Elferen, S., Nies, M., Schenker, N., Lemoine, M. D., Welcker, A., Kany, S., Rottner, L., Ismaili, D., Sommerfeld, L. C., Petersen, J., Govorov, K., Schoof, L., Tsoy, O., Baumbach, J., Pecha, S., Zeller, T., ... Kirchhof, P. (2026). Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study. European Heart Journal Open, 6(1), oeag002. https://doi.org/10.1093/ehjopen/oeag002

@article{a1b0ce4747ef47ec9c0126e9aa71c976,

title = "Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study",

abstract = "AIMS: Optimal outcomes for patients with cardiac arrhythmias can be achieved through multimodal therapy including lifestyle support, medication, and interventions. Planning of these therapy concepts requires a detailed understanding of phenotypes, responses to therapies, and outcomes.OBJECTIVE: The prospective Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg (TRUST) combines deep phenotypic, procedural, and follow-up information in a contemporary cohort of patients with cardiac arrhythmias.METHODS AND RESULTS: TRUST is an investigator-initiated, prospective, cohort study enrolling consecutive patients at the UHZ Hamburg. Comprehensive baseline work-up, imaging, and biobanking at baseline is combined with follow-up using a combination of in-person visits, online questionnaires, and remote rhythm-monitoring. Enrolment started in March 2021 and is ongoing. This paper describes the design and the clinical characteristics of the first 1500 enrolled patients with verified baseline datasets (562 women (37\%), median age 64 (IQR 55, 74) years). Overall, 1077/1500 patients (71\%) were seen for atrial fibrillation, 161/1500 (11\%) for ventricular tachycardia and premature ventricular complexes, 239/1500 (16\%) for supraventricular tachycardia, and 23/1500 (2\%) patients for other reasons. Ablations, rhythm surgery, or invasive procedures were performed in 1363/1500 (91\%) within 1 month after inclusion.CONCLUSION: This snapshot of the first 1500 patients enrolled in TRUST illustrates current characteristics and comorbidity burden in patients undergoing arrhythmia treatment. This rich data set will provide information on treatment patterns, detailed phenotypes, and follow-up, offering insights into the natural progression and treatment responses of arrhythmias in routine care.",

author = "Julius Obergassel and Rie{\ss}, \{Jan Leon\} and Sandro Jaeckle and \{van Elferen\}, Silke and Moritz Nies and Niklas Schenker and Lemoine, \{Marc Daniel\} and Alexander Welcker and Shinwan Kany and Laura Rottner and Djemail Ismaili and Sommerfeld, \{Laura Charlotte\} and Johannes Petersen and Katharina Govorov and Lauritz Schoof and Olga Tsoy and Jan Baumbach and Simon Pecha and Tanja Zeller and Stefan Blankenberg and Larissa Fabritz and Bruno Rei{\ss}mann and Feifan Ouyang and Andreas Rillig and Andreas Metzner and Paulus Kirchhof",

note = "{\textcopyright} The Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology.",

year = "2026",

month = jan,

doi = "10.1093/ehjopen/oeag002",

language = "English",

volume = "6",

pages = "oeag002",

journal = "European Heart Journal Open",

issn = "2752-4191",

publisher = "Oxford University Press",

number = "1",

}

Obergassel, J, Rieß, JL, Jaeckle, S, van Elferen, S, Nies, M, Schenker, N, Lemoine, MD, Welcker, A, Kany, S, Rottner, L, Ismaili, D, Sommerfeld, LC, Petersen, J, Govorov, K, Schoof, L, Tsoy, O, Baumbach, J, Pecha, S, Zeller, T, Blankenberg, S, Fabritz, L, Reißmann, B, Ouyang, F, Rillig, A, Metzner, A & Kirchhof, P 2026, 'Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study', European Heart Journal Open, vol. 6, no. 1, pp. oeag002. https://doi.org/10.1093/ehjopen/oeag002

Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study. / Obergassel, Julius; Rieß, Jan Leon; Jaeckle, Sandro et al.
In: European Heart Journal Open, Vol. 6, No. 1, 01.2026, p. oeag002.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST)

T2 - design and patient profile snapshot of a prospective clinical cohort study

AU - Obergassel, Julius

AU - Rieß, Jan Leon

AU - Jaeckle, Sandro

AU - van Elferen, Silke

AU - Nies, Moritz

AU - Schenker, Niklas

AU - Lemoine, Marc Daniel

AU - Welcker, Alexander

AU - Kany, Shinwan

AU - Rottner, Laura

AU - Ismaili, Djemail

AU - Sommerfeld, Laura Charlotte

AU - Petersen, Johannes

AU - Govorov, Katharina

AU - Schoof, Lauritz

AU - Tsoy, Olga

AU - Baumbach, Jan

AU - Pecha, Simon

AU - Zeller, Tanja

AU - Blankenberg, Stefan

AU - Fabritz, Larissa

AU - Reißmann, Bruno

AU - Ouyang, Feifan

AU - Rillig, Andreas

AU - Metzner, Andreas

AU - Kirchhof, Paulus

PY - 2026/1

Y1 - 2026/1

N2 - AIMS: Optimal outcomes for patients with cardiac arrhythmias can be achieved through multimodal therapy including lifestyle support, medication, and interventions. Planning of these therapy concepts requires a detailed understanding of phenotypes, responses to therapies, and outcomes.OBJECTIVE: The prospective Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg (TRUST) combines deep phenotypic, procedural, and follow-up information in a contemporary cohort of patients with cardiac arrhythmias.METHODS AND RESULTS: TRUST is an investigator-initiated, prospective, cohort study enrolling consecutive patients at the UHZ Hamburg. Comprehensive baseline work-up, imaging, and biobanking at baseline is combined with follow-up using a combination of in-person visits, online questionnaires, and remote rhythm-monitoring. Enrolment started in March 2021 and is ongoing. This paper describes the design and the clinical characteristics of the first 1500 enrolled patients with verified baseline datasets (562 women (37%), median age 64 (IQR 55, 74) years). Overall, 1077/1500 patients (71%) were seen for atrial fibrillation, 161/1500 (11%) for ventricular tachycardia and premature ventricular complexes, 239/1500 (16%) for supraventricular tachycardia, and 23/1500 (2%) patients for other reasons. Ablations, rhythm surgery, or invasive procedures were performed in 1363/1500 (91%) within 1 month after inclusion.CONCLUSION: This snapshot of the first 1500 patients enrolled in TRUST illustrates current characteristics and comorbidity burden in patients undergoing arrhythmia treatment. This rich data set will provide information on treatment patterns, detailed phenotypes, and follow-up, offering insights into the natural progression and treatment responses of arrhythmias in routine care.

AB - AIMS: Optimal outcomes for patients with cardiac arrhythmias can be achieved through multimodal therapy including lifestyle support, medication, and interventions. Planning of these therapy concepts requires a detailed understanding of phenotypes, responses to therapies, and outcomes.OBJECTIVE: The prospective Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg (TRUST) combines deep phenotypic, procedural, and follow-up information in a contemporary cohort of patients with cardiac arrhythmias.METHODS AND RESULTS: TRUST is an investigator-initiated, prospective, cohort study enrolling consecutive patients at the UHZ Hamburg. Comprehensive baseline work-up, imaging, and biobanking at baseline is combined with follow-up using a combination of in-person visits, online questionnaires, and remote rhythm-monitoring. Enrolment started in March 2021 and is ongoing. This paper describes the design and the clinical characteristics of the first 1500 enrolled patients with verified baseline datasets (562 women (37%), median age 64 (IQR 55, 74) years). Overall, 1077/1500 patients (71%) were seen for atrial fibrillation, 161/1500 (11%) for ventricular tachycardia and premature ventricular complexes, 239/1500 (16%) for supraventricular tachycardia, and 23/1500 (2%) patients for other reasons. Ablations, rhythm surgery, or invasive procedures were performed in 1363/1500 (91%) within 1 month after inclusion.CONCLUSION: This snapshot of the first 1500 patients enrolled in TRUST illustrates current characteristics and comorbidity burden in patients undergoing arrhythmia treatment. This rich data set will provide information on treatment patterns, detailed phenotypes, and follow-up, offering insights into the natural progression and treatment responses of arrhythmias in routine care.

U2 - 10.1093/ehjopen/oeag002

DO - 10.1093/ehjopen/oeag002

M3 - Journal articles

C2 - 41743284

SN - 2752-4191

VL - 6

SP - oeag002

JO - European Heart Journal Open

JF - European Heart Journal Open

IS - 1

ER -

Obergassel J, Rieß JL, Jaeckle S, van Elferen S, Nies M, Schenker N et al. Long-term outcome and predictors for recurrence after medical and interventional treatment of arrhythmias at the UniverSity Heart CenTer Hamburg (TRUST): design and patient profile snapshot of a prospective clinical cohort study. European Heart Journal Open. 2026 Jan;6(1):oeag002. doi: 10.1093/ehjopen/oeag002