TY - JOUR
T1 - Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects
AU - Kieninger, Elisabeth
AU - Singer, Florian
AU - Fuchs, Oliver
AU - Abbas, Chiara
AU - Frey, Urs
AU - Regamey, Nicolas
AU - Casaulta, Carmen
AU - Latzin, Philipp
N1 - Funding Information:
Supported by the Swiss Confederation's Innovation Promotion Agency (CTI) grant no. 11661.1 PFLS-LS and the “Fondazione Ettore e Valeria Rossi”.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12
Y1 - 2011/12
N2 - Multiple breath washout (MBW) measurements have recently been shown to be sensitive for detection of early cystic fibrosis (CF) lung disease, with the lung clearance index (LCI) being the most common measure for ventilation inhomogeneity. The aim of this observational study was to describe the longitudinal course of LCI from time of clinical diagnosis during infancy to school-age in eleven children with CF. Elevated LCI during infancy was present in seven subjects, especially in those with later clinical diagnosis. Tracking of LCI at follow-up was evident only in the four most severe cases. We provide the first longitudinal data describing the long-term course of LCI in a small group of infants with CF. Our findings support the clinical usefulness of MBW measurements to detect and monitor early lung disease in children with CF already present shortly after clinical diagnosis.
AB - Multiple breath washout (MBW) measurements have recently been shown to be sensitive for detection of early cystic fibrosis (CF) lung disease, with the lung clearance index (LCI) being the most common measure for ventilation inhomogeneity. The aim of this observational study was to describe the longitudinal course of LCI from time of clinical diagnosis during infancy to school-age in eleven children with CF. Elevated LCI during infancy was present in seven subjects, especially in those with later clinical diagnosis. Tracking of LCI at follow-up was evident only in the four most severe cases. We provide the first longitudinal data describing the long-term course of LCI in a small group of infants with CF. Our findings support the clinical usefulness of MBW measurements to detect and monitor early lung disease in children with CF already present shortly after clinical diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=81455154503&partnerID=8YFLogxK
U2 - 10.1016/j.jcf.2011.07.006
DO - 10.1016/j.jcf.2011.07.006
M3 - Journal articles
C2 - 21835702
AN - SCOPUS:81455154503
SN - 1569-1993
VL - 10
SP - 487
EP - 490
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
IS - 6
ER -
