Localized linear IgA disease induced by ampicillin/sulbactam

Iakov Shimanovich; Christian Rose; Cassian Sitaru; Eva B. Bröcker; Detlef Zillikens

doi:10.1016/j.jaad.2004.03.027

Localized linear IgA disease induced by ampicillin/sulbactam

Iakov Shimanovich, Christian Rose, Cassian Sitaru, Eva B. Bröcker, Detlef Zillikens^*

^*Corresponding author for this work

Department of Dermatology, Allergology and Venereology

University of Würzburg

30 Citations (Scopus)

Abstract

We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	51
Issue number	1
Pages (from-to)	95-98
Number of pages	4
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2004.03.027
Publication status	Published - 07.2004

Funding

Supported by grant 98.073.2 from the Wilhelm Sander-Stiftung, Munich, Germany.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.jaad.2004.03.027

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title = "Localized linear IgA disease induced by ampicillin/sulbactam",

abstract = "We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.",

author = "Iakov Shimanovich and Christian Rose and Cassian Sitaru and Br{\"o}cker, \{Eva B.\} and Detlef Zillikens",

note = "Funding Information: Supported by grant 98.073.2 from the Wilhelm Sander-Stiftung, Munich, Germany. ",

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AU - Shimanovich, Iakov

AU - Rose, Christian

AU - Sitaru, Cassian

AU - Bröcker, Eva B.

AU - Zillikens, Detlef

N1 - Funding Information: Supported by grant 98.073.2 from the Wilhelm Sander-Stiftung, Munich, Germany.

PY - 2004/7

Y1 - 2004/7

N2 - We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

AB - We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

UR - https://www.scopus.com/pages/publications/3042737603

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DO - 10.1016/j.jaad.2004.03.027

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JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 1

ER -

Localized linear IgA disease induced by ampicillin/sulbactam

Abstract

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UN SDGs

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