Localized linear IgA disease induced by ampicillin/sulbactam

Iakov Shimanovich, Christian Rose, Cassian Sitaru, Eva B. Bröcker, Detlef Zillikens*

*Corresponding author for this work
26 Citations (Scopus)


We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.

Original languageEnglish
JournalJournal of the American Academy of Dermatology
Issue number1
Pages (from-to)95-98
Number of pages4
Publication statusPublished - 07.2004


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