Abstract
We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.
Original language | English |
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Journal | Journal of the American Academy of Dermatology |
Volume | 51 |
Issue number | 1 |
Pages (from-to) | 95-98 |
Number of pages | 4 |
ISSN | 0190-9622 |
DOIs | |
Publication status | Published - 07.2004 |