Localized Ewing tumor of bone: Final results of the Cooperative Ewing's Sarcoma Study CESS 86

M. Paulussen*, S. Ahrens, J. Dunst, W. Winkelmann, G. U. Exner, R. Kotz, G. Amann, B. Dockhorn-Dworniczak, D. Harms, S. Müller-Weihrich, K. Welte, B. Kornhuber, G. Janka-Schaub, U. Göbel, J. Treuner, P. A. Voûte, A. Zoubek, H. Gadner, H. Jürgens

*Corresponding author for this work
306 Citations (Scopus)

Abstract

Purpose: Cooperative Ewing's Sarcoma Study (CESS) 86 aimed at improving event-free survival (EFS) in patients with high-risk localized Ewing tumor of bone. Patients and Methods: We analyzed 301 patients recruited from January 1986 to July 1991 (60% male; median age 15 years). Tumors of volume >100 mL and/or at central-axis sites qualified patients for "high risk" (HR, n = 241), and small extremity lesions for "standard risk" (SR, n = 52). Standard-risk patients received 12 courses of vincristine, cyclophosphamide, and doxorubicin alternating with actinomycin D (VACA); HR patients received ifosfamide instead of cyclophosphamide (VAIA). Tumor sites were pelvis (27%), other central axis (28%), femur (19%), or other extremity (26%). The initial tumor volume was <100 mL in 33% of cases and ≥100 mL in 67%. Local therapy was surgery (23%), surgery plus radiotherapy (49%), or radiotherapy alone (28%). Event-free survival rates were estimated by Kaplan-Meier analyses, comparisons were done by log-rank test, and risk factors were analyzed by Cox models. Results: On May 1, 1999 (median time under study, 133 months), the 10-year EFS was 0.52. Event-free survival did not differ between SR-VACA (0.52) and HR-VAIA (0.51, P = .92). Tumor volume of >200 mL (EFS, 0.36 v 0.63 for smaller tumors; P = .0001) and poor histologic response (EFS, 0.38 v 0.64 for good responders; P = .0007) had negative impacts on EFS. In multivariate analyses, small tumor volumes of <200 mL, good histologic response, and VAIA chemotherapy augured for fair outcome. Six of 301 patients (2%) died under treatment, and four patients (1.3%) developed second malignancies. Conclusion: Fifty-two percent of CESS 86 patients survived after risk-adapted therapy. High-risk patients seem to have benefited from intensified treatment that incorporated ifosfamide.

Original languageEnglish
JournalJournal of Clinical Oncology
Volume19
Issue number6
Pages (from-to)1818-1829
Number of pages12
ISSN0732-183X
DOIs
Publication statusPublished - 15.03.2001

Fingerprint

Dive into the research topics of 'Localized Ewing tumor of bone: Final results of the Cooperative Ewing's Sarcoma Study CESS 86'. Together they form a unique fingerprint.

Cite this