Local wavefront mapping in tissue using computational adaptive optics OCT

Fredrick A. South, Yuan Zhi Liu, Pin Chieh Huang, Tabea Kohlfarber, Stephen A. Boppart*

*Corresponding author for this work
3 Citations (Scopus)


The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.

Original languageEnglish
JournalOptics Letters
Issue number5
Pages (from-to)1186-1189
Number of pages4
Publication statusPublished - 01.03.2019

Research Areas and Centers

  • Academic Focus: Biomedical Engineering


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