TY - JOUR
T1 - Linking MLL and the HGF-MET signaling pathway in liver cancer
AU - Marquardt, Jens U.
AU - Thorgeirsson, Snorri S.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Mixed-lineage leukemia (MLL; also known as myeloid/lymphoid), the human homolog of trithorax in Drosophila, is a transcriptional coactivator that plays an essential role during early development and hematopoiesis. Furthermore, MLL is critically involved in the epigenetic regulation of cell cycle, senescence, DNA damage, and stem cell self-renewal. Chromosomal aberrations of MLL in acute leukemias are well documented, but the role of this gene in solid malignancies remains unclear. In this issue of the JCI, Takeda et al. describe a novel epigenetic link between MLL and the HGF-MET signaling pathway conferring invasive and metastatic properties to hepatocellular carcinoma cells.
AB - Mixed-lineage leukemia (MLL; also known as myeloid/lymphoid), the human homolog of trithorax in Drosophila, is a transcriptional coactivator that plays an essential role during early development and hematopoiesis. Furthermore, MLL is critically involved in the epigenetic regulation of cell cycle, senescence, DNA damage, and stem cell self-renewal. Chromosomal aberrations of MLL in acute leukemias are well documented, but the role of this gene in solid malignancies remains unclear. In this issue of the JCI, Takeda et al. describe a novel epigenetic link between MLL and the HGF-MET signaling pathway conferring invasive and metastatic properties to hepatocellular carcinoma cells.
UR - http://www.scopus.com/inward/record.url?scp=84879625617&partnerID=8YFLogxK
U2 - 10.1172/JCI70235
DO - 10.1172/JCI70235
M3 - Comments/Debates
C2 - 23934122
AN - SCOPUS:84879625617
SN - 0021-9738
VL - 123
SP - 2780
EP - 2783
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 7
ER -
