Linked Data Applications Through Ontology Based Data Access in Clinical Research

Ann Kristin Kock-Schoppenhauer, Christian Kamann, Hannes Ulrich, Petra Duhm-Harbeck, Josef Ingenerf*

*Corresponding author for this work


Clinical care and research data are widely dispersed in isolated systems based on heterogeneous data models. Biomedicine predominantly makes use of connected datasets based on the Semantic Web paradigm. Initiatives like Bio2RDF created Resource Description Framework (RDF) versions of Omics resources, enabling sophisticated Linked Data applications. In contrast, electronic healthcare records (EHR) data are generated and processed in diverse clinical subsystems within hospital information systems (HIS). Usually, each of them utilizes a relational database system with a different proprietary schema. Semantic integration and access to the data is hardly possible. This paper describes ways of using Ontology Based Data Access (OBDA) for bridging the semantic gap between existing raw data and user-oriented views supported by ontology-based queries. Based on mappings between entities of data schemas and ontologies data can be made available as materialized or virtualized RDF triples ready for querying and processing. Our experiments based on CentraXX for biobank and study management demonstrate the advantages of abstracting away from low level details and semantic mediation. Furthermore, it becomes clear that using a professional platform for Linked Data applications is recommended due to the inherent complexity, the inconvenience to confront end users with SPARQL, and scalability and performance issues.

Original languageEnglish
Title of host publicationInformatics for Health: Connected Citizen-Led Wellness and Population Health
EditorsR. Randell, R. Cornet, C. McCowan, N. Peek, P. J. Scott
Number of pages5
PublisherIOS Press
Publication date01.01.2017
ISBN (Print)978-1-61499-752-8
ISBN (Electronic)978-1-61499-753-5
Publication statusPublished - 01.01.2017
EventInformatics for Health 2017 - Manchester , United Kingdom
Duration: 24.04.201726.04.2017


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