TY - JOUR
T1 - Light Entrainment of the Mammalian Circadian Clock by a PRKCA-Dependent Posttranslational Mechanism
AU - Jakubcakova, Vladimira
AU - Oster, Henrik
AU - Tamanini, Filippo
AU - Cadenas, Cristina
AU - Leitges, Michael
AU - van der Horst, Gijsbertus T.J.
AU - Eichele, Gregor
PY - 2007/6/7
Y1 - 2007/6/7
N2 - Light is the most potent stimulus for synchronizing endogenous circadian rhythms with external time. Photic clock resetting in mammals involves cAMP-responsive element binding protein (CREB)-mediated transcriptional activation of Period clock genes in the suprachiasmatic nuclei (SCN). Here we provide evidence for an additional photic input pathway to the mammalian circadian clock based on Protein Kinase C α (PRKCA). We found that Prkca-deficient mice show an impairment of light-mediated clock resetting. In the SCN of wild-type mice, light exposure evokes a transient interaction between PRKCA and PERIOD 2 (PER2) proteins that affects PER2 stability and nucleocytoplasmic distribution. These posttranslational events, together with CREB-mediated transcriptional regulation, are key factors in the molecular mechanism of photic clock resetting.
AB - Light is the most potent stimulus for synchronizing endogenous circadian rhythms with external time. Photic clock resetting in mammals involves cAMP-responsive element binding protein (CREB)-mediated transcriptional activation of Period clock genes in the suprachiasmatic nuclei (SCN). Here we provide evidence for an additional photic input pathway to the mammalian circadian clock based on Protein Kinase C α (PRKCA). We found that Prkca-deficient mice show an impairment of light-mediated clock resetting. In the SCN of wild-type mice, light exposure evokes a transient interaction between PRKCA and PERIOD 2 (PER2) proteins that affects PER2 stability and nucleocytoplasmic distribution. These posttranslational events, together with CREB-mediated transcriptional regulation, are key factors in the molecular mechanism of photic clock resetting.
UR - http://www.scopus.com/inward/record.url?scp=34249650212&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2007.04.031
DO - 10.1016/j.neuron.2007.04.031
M3 - Journal articles
C2 - 17553429
AN - SCOPUS:34249650212
SN - 0896-6273
VL - 54
SP - 831
EP - 843
JO - Neuron
JF - Neuron
IS - 5
ER -
