Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany

Hans Joergen Grabe; Christian Meyer; Ulfert Hapke; Hans Juergen Rumpf; Harald Juergen Freyberger; Horst Dilling; Ulrich John

doi:10.1007/s004060170047

Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany

Hans Joergen Grabe^*, Christian Meyer, Ulfert Hapke, Hans Juergen Rumpf, Harald Juergen Freyberger, Horst Dilling, Ulrich John

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

University of Greifswald

88 Citations (Scopus)

Abstract

Objective: Inspite of the worldwide relevance of obsessive-compulsive disorder (OCD), there is a substantial lack of data on comorbidity in OCD and subclinical OCD in the general population. Methods: German versions of the DSM-IV adapted Composite International Diagnostic Interview were administered to a representative sample of 4075 persons aged 18-64 years, living in a northern German region. Results In both genders, high rates of comorbid depressive disorders were found in OCD and subclinical OCD, whereas somatoform pain disorder was only associated with OCD. In female subjects, OCD was additionally associated with social and specific phobias, alcohol, nicotine and sedative dependence, PTSD and atypical eating disorder. Conclusion Due to low comorbidity rates, subclinical OCD seems to represent an independent syndrome not restricted to the presence of other axis-I diagnoses. Comorbidity patterns show a disposition to anxiety and to depressive disorders in OCD and subclinical OCD. A broad association with obsessive-compulsive spectrum disorders could not be confirmed in our general population sample.

Original language	English
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	251
Issue number	3
Pages (from-to)	130-135
Number of pages	6
ISSN	0940-1334
DOIs	https://doi.org/10.1007/s004060170047
Publication status	Published - 2001

Funding

■ Acknowledgments This study is part of the German research network“Analytical Epidemiology of Substance Abuse (ANEPSA)”. Factors related to the use and abuse of psychoactive substances are analyzed by different research groups in the context of several longitudinal studies. Contact persons are Dr. Büringer/Dr. Küfner (IFT Institute for Therapy Research, Munich), Prof. Dr. Wittchen (Max-Planck Institute, Munich) and Prof. Dr. John (University of Greifswald)/Prof. Dr. Dilling (Medical University of Lübeck). The research network is funded in the context of the program “Biological and psycho-social factors of drug abuse and dependence”by the Federal Ministry of Education, Science, Research, and Technology.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1007/s004060170047

Cite this

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title = "Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany",

abstract = "Objective: Inspite of the worldwide relevance of obsessive-compulsive disorder (OCD), there is a substantial lack of data on comorbidity in OCD and subclinical OCD in the general population. Methods: German versions of the DSM-IV adapted Composite International Diagnostic Interview were administered to a representative sample of 4075 persons aged 18-64 years, living in a northern German region. Results In both genders, high rates of comorbid depressive disorders were found in OCD and subclinical OCD, whereas somatoform pain disorder was only associated with OCD. In female subjects, OCD was additionally associated with social and specific phobias, alcohol, nicotine and sedative dependence, PTSD and atypical eating disorder. Conclusion Due to low comorbidity rates, subclinical OCD seems to represent an independent syndrome not restricted to the presence of other axis-I diagnoses. Comorbidity patterns show a disposition to anxiety and to depressive disorders in OCD and subclinical OCD. A broad association with obsessive-compulsive spectrum disorders could not be confirmed in our general population sample.",

author = "Grabe, \{Hans Joergen\} and Christian Meyer and Ulfert Hapke and Rumpf, \{Hans Juergen\} and Freyberger, \{Harald Juergen\} and Horst Dilling and Ulrich John",

note = "Funding Information: ■ Acknowledgments This study is part of the German research network“Analytical Epidemiology of Substance Abuse (ANEPSA)”. Factors related to the use and abuse of psychoactive substances are analyzed by different research groups in the context of several longitudinal studies. Contact persons are Dr. B{\"u}ringer/Dr. K{\"u}fner (IFT Institute for Therapy Research, Munich), Prof. Dr. Wittchen (Max-Planck Institute, Munich) and Prof. Dr. John (University of Greifswald)/Prof. Dr. Dilling (Medical University of L{\"u}beck). The research network is funded in the context of the program “Biological and psycho-social factors of drug abuse and dependence”by the Federal Ministry of Education, Science, Research, and Technology. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1007/s004060170047",

language = "English",

volume = "251",

pages = "130--135",

journal = "European Archives of Psychiatry and Clinical Neuroscience",

issn = "0940-1334",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "3",

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T1 - Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany

AU - Grabe, Hans Joergen

AU - Meyer, Christian

AU - Hapke, Ulfert

AU - Rumpf, Hans Juergen

AU - Freyberger, Harald Juergen

AU - Dilling, Horst

AU - John, Ulrich

N1 - Funding Information: ■ Acknowledgments This study is part of the German research network“Analytical Epidemiology of Substance Abuse (ANEPSA)”. Factors related to the use and abuse of psychoactive substances are analyzed by different research groups in the context of several longitudinal studies. Contact persons are Dr. Büringer/Dr. Küfner (IFT Institute for Therapy Research, Munich), Prof. Dr. Wittchen (Max-Planck Institute, Munich) and Prof. Dr. John (University of Greifswald)/Prof. Dr. Dilling (Medical University of Lübeck). The research network is funded in the context of the program “Biological and psycho-social factors of drug abuse and dependence”by the Federal Ministry of Education, Science, Research, and Technology. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - Objective: Inspite of the worldwide relevance of obsessive-compulsive disorder (OCD), there is a substantial lack of data on comorbidity in OCD and subclinical OCD in the general population. Methods: German versions of the DSM-IV adapted Composite International Diagnostic Interview were administered to a representative sample of 4075 persons aged 18-64 years, living in a northern German region. Results In both genders, high rates of comorbid depressive disorders were found in OCD and subclinical OCD, whereas somatoform pain disorder was only associated with OCD. In female subjects, OCD was additionally associated with social and specific phobias, alcohol, nicotine and sedative dependence, PTSD and atypical eating disorder. Conclusion Due to low comorbidity rates, subclinical OCD seems to represent an independent syndrome not restricted to the presence of other axis-I diagnoses. Comorbidity patterns show a disposition to anxiety and to depressive disorders in OCD and subclinical OCD. A broad association with obsessive-compulsive spectrum disorders could not be confirmed in our general population sample.

AB - Objective: Inspite of the worldwide relevance of obsessive-compulsive disorder (OCD), there is a substantial lack of data on comorbidity in OCD and subclinical OCD in the general population. Methods: German versions of the DSM-IV adapted Composite International Diagnostic Interview were administered to a representative sample of 4075 persons aged 18-64 years, living in a northern German region. Results In both genders, high rates of comorbid depressive disorders were found in OCD and subclinical OCD, whereas somatoform pain disorder was only associated with OCD. In female subjects, OCD was additionally associated with social and specific phobias, alcohol, nicotine and sedative dependence, PTSD and atypical eating disorder. Conclusion Due to low comorbidity rates, subclinical OCD seems to represent an independent syndrome not restricted to the presence of other axis-I diagnoses. Comorbidity patterns show a disposition to anxiety and to depressive disorders in OCD and subclinical OCD. A broad association with obsessive-compulsive spectrum disorders could not be confirmed in our general population sample.

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Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany

Abstract

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