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LifeTime and improving European healthcare through cell-based interceptive medicine

  • LifeTime Community
  • Charite - Universitatsmedizin Berlin
  • Institut Curie
  • Max Delbrück Center for Molecular Medicine
  • KU Leuven
  • The Weizmann Institute of Science
  • University of Vienna
  • Utrecht University
  • Université Montpellier I
  • Division of Epidemiology and Biostatics
  • University of London
  • European Molecular Biology Laboratory Heidelberg (EMBL)
  • Poznan University of Technology
  • University of Basel
  • Aarhus University
  • German Cancer Research Center
  • Karolinska Institutet
  • University of Cambridge
  • Unversitat Pompeu Fabra
  • Radboud University Nijmegen
  • University of Bonn
  • VIB Technology Watch
  • European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
  • University of Padova
  • Humboldt University of Berlin
  • University of Kiel
  • German Centre for Neurodegenerative Diseases (DZNE)
  • University of Milan
  • Academy of Athens
  • Technical University of Munich
  • Ludwig-Maximilians-Universität
  • Catalan Institution for Research and Advanced Studies

Abstract

LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be achieved through interactions across academia, hospitals, patient-associations, health data management systems and industry. Applying this strategy to key medical challenges in cancer, neurological, infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

Original languageEnglish
JournalNature
ISSN0028-0836
DOIs
Publication statusPublished - 07.09.2020

Funding

Acknowledgements We acknowledge all participants that have attended and contributed to LifeTime meetings and workshops through many presentations and discussions. We thank J. Richers for artwork and A. Sonsala, A. Tschernycheff and C. Lozach for administrative support. LifeTime has received funding from the European Union’s Horizon 2020 research and innovation framework programme under grant agreement 820431.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Research Areas and Centers

  • Research Area: Medical Genetics

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