LFA-1 in T cell priming, differentiation, and effector functions

Audrey Gérard, Andrew P. Cope, Claudia Kemper, Ronen Alon, Robert Köchl*

*Corresponding author for this work
32 Citations (Scopus)

Abstract

The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or APCs. These include roles in homotypic T cell–T cell (T–T) communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.

Original languageEnglish
JournalTrends in Immunology
Volume42
Issue number8
Pages (from-to)706-722
Number of pages17
ISSN1471-4906
DOIs
Publication statusPublished - 08.2021

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 204-05 Immunology

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