Leptin Raises Defended Body Temperature without Activating Thermogenesis

Alexander W. Fischer, Carolin S. Hoefig, Gustavo Abreu-Vieira, Jasper M.A. de Jong, Natasa Petrovic, Jens Mittag, Barbara Cannon, Jan Nedergaard*

*Corresponding author for this work
39 Citations (Scopus)


Leptin has been believed to exert its weight-reducing action not only by inducing hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient ob/ob mice have correspondingly been thought to be thermogenically limited and to show hypothermia, mainly due to atrophied brown adipose tissue (BAT). In contrast to these established views, we found that BAT is fully functional and that leptin treatment did not increase thermogenesis in wild-type or in ob/ob mice. Rather, ob/ob mice showed a decreased but defended body temperature (i.e., were anapyrexic, not hypothermic) that was normalized to wild-type levels after leptin treatment. This was not accompanied by increased energy expenditure or BAT recruitment but, instead, was mediated by decreased tail heat loss. The weight-reducing hypophagic effects of leptin are, therefore, not augmented through a thermogenic effect of leptin; leptin is, however, pyrexic, i.e., it alters centrally regulated thresholds of thermoregulatory mechanisms, in parallel to effects of other cytokines.

Original languageEnglish
JournalCell Reports
Issue number7
Pages (from-to)1621-1631
Number of pages11
Publication statusPublished - 23.02.2016

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


Dive into the research topics of 'Leptin Raises Defended Body Temperature without Activating Thermogenesis'. Together they form a unique fingerprint.

Cite this