Abstract
Local infection of mice with Leishmania major results in either healing or death depending on the preferential action of Th1 or Th2 T helper cells, respectively. Although the parasite-induced T-cell responses and their consequences for the disease are well understood, relatively little is known about the initial events that kindle the adaptive immune response. Werner Salbach and Tamás Laskay here discuss how differences in parasites spreading from the site of infection to different immune organs during the first 10-24 hours and, in consequence, the 'where and when' of the first encounter of Leishmania with the cells of the immune system may well be the starting point for the development of resistance or susceptibility.
| Original language | English |
|---|---|
| Journal | Parasitology Today |
| Volume | 11 |
| Issue number | 10 |
| Pages (from-to) | 394-397 |
| Number of pages | 4 |
| ISSN | 0169-4758 |
| DOIs | |
| Publication status | Published - 01.01.1995 |
Funding
This investigation received financial support from UNDPiWotid Bank/WHO Special Programme for Research and Tralnlng In TropIcal Diseases (TDR. grant 930330). Work also partially supported by Consello Naclonal de Deslnvolvlmento Clentlfico e Tecnologlco (CNPq) and Flnanclng Agency of Studies and Projects (FINEP) (Brasil). MFL IS supported by a CAPES/ME doctoral fellowship. jects ranging from molecular phylogeny to treatment of human patients necessarily has led to a scattering of literature in many different (often quite exotic) loumals which are not always easy to obtain. In 1986, RCA. Thompson brought the existing information together by editing a multi-author volume’, which rapidly became a standard reference for the workers in the field. The book on review IS essentially a second edition of the previous work Incorporating the fruits of the past nine years of research. The volume is divided Into ten chapters, each one being an independent review article written by experts in the respective field: ‘Biology and sys- for critical reading of the manuscript.O ur own work reported here was supportedb y DFG (SFB 263/A I).
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
