Leishmania major infection: the overture

5 Citations (Scopus)


Local infection of mice with Leishmania major results in either healing or death depending on the preferential action of Th1 or Th2 T helper cells, respectively. Although the parasite-induced T-cell responses and their consequences for the disease are well understood, relatively little is known about the initial events that kindle the adaptive immune response. Werner Salbach and Tamás Laskay here discuss how differences in parasites spreading from the site of infection to different immune organs during the first 10-24 hours and, in consequence, the 'where and when' of the first encounter of Leishmania with the cells of the immune system may well be the starting point for the development of resistance or susceptibility.

Original languageEnglish
JournalParasitology Today
Issue number10
Pages (from-to)394-397
Number of pages4
Publication statusPublished - 01.01.1995

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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