Objective Our study aimed to evaluate myocardial adaption and outcome after transfemoral aortic valve implantation (TAVI TF) for severe aortic stenosis by LV ejection fraction (LVEF) and speckle tracking analysis. Methods and results From 168 patients who underwent TAVI TF between 2010 and 2013 in our institution, n = 95 with a follow-up period ≥ 3 months were included and grouped (G) according to baseline left ventricular ejection fraction (LVEF; G1: LVEF < 40%, G2: 40%–55%, G3: > 55%). LV function was evaluated using conventional and speckle-tracking based parameters. Mortality was tracked up to 60 months. Aortic valve orifice diameter and mean aortic gradient improved significantly after TAVI. LV dimensions and LVEF remained largely unchanged. Systolic function significantly improved in G1 (LVEF, p < 0.001, global longitudinal strain [GLS], p = 0.02) but deteriorated in G3 (LVEF, p = 0.004, GLS, p = 0.03). It did not change in G2. Diastolic function parameters improved significantly only in G3. Changes of LVEF and GLS were also statistically significant between G1 and G3 (LVEF p < 0.0001, GLS p = 0.004). Patients exhibited a higher survival rate with an LVEF increase > 8% than with LVEF deterioration > 8% (p = 0.04). GLS changes had no significant impact on mortality. Conclusion In patient with aortic stenosis and LVEF impairment at baseline, TAVI results in an improved LVEF, while patients with a high LVEF at baseline experience a normalization of LVEF after TAVI. Independent of the baseline value, a deterioration of LVEF leads to a significant increase in mortality.