Learning Deformable Point Set Registration with Regularized Dynamic Graph CNNs for Large Lung Motion in COPD Patients

Lasse Hansen*, Doris Dittmer, Mattias P. Heinrich

*Corresponding author for this work


Deformable registration continues to be one of the key challenges in medical image analysis. While iconic registration methods have started to benefit from the recent advances in medical deep learning, the same does not yet apply for the registration of point sets, e.g. registration based on surfaces, keypoints or landmarks. This is mainly due to the restriction of the convolution operator in modern CNNs to densely gridded input. However, with the newly developed methods from the field of geometric deep learning suitable tools are now emerging, which enable powerful analysis of medical data on irregular domains. In this work, we present a new method that enables the learning of regularized feature descriptors with dynamic graph CNNs. By incorporating the learned geometric features as prior probabilities into the well-established coherent point drift (CPD) algorithm, formulated as differentiable network layer, we establish an end-to-end framework for robust registration of two point sets. Our approach is evaluated on the challenging task of aligning keypoints extracted from lung CT scans in inhale and exhale states with large deformations and without any additional intensity information. Our results indicate that the inherent geometric structure of the extracted keypoints is sufficient to establish descriptive point features, which yield a significantly improved performance and robustness of our registration framework.

Original languageEnglish
Title of host publicationGLMI 2019: Graph Learning in Medical Imaging
EditorsDaoqiang Zhang, Luping Zhou, Biao Jie, Mingxia Liu
Number of pages9
Volume11849 LNCS
PublisherSpringer, Cham
Publication date14.11.2019
ISBN (Print)978-3-030-35816-7
ISBN (Electronic)978-3-030-35817-4
Publication statusPublished - 14.11.2019
Event22nd International Conference on Medical Image Computing and Computer-Assisted Intervention - Shenzhen, China
Duration: 13.10.201917.10.2019
Conference number: 232939


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