Lear-cell variant urothelial carcinoma of the bladder: A case report and review of the literature

Mario W. Kramer, Mahmoud Abbas, Stefanie Pertschy, Jan Ulrich Becker, Hans Heinrich Kreipe, Markus A. Kuczyk, Axel S. Merseburger, Hossein Teival*

*Corresponding author for this work
15 Citations (Scopus)


Clear cell variants of transitional cell carcinomas (TCC) of the bladder are extremely rare tumors. Only 6 cases have been reported until now. We report of a 67 year old man who presented with fast growing tumor disease. While initial diagnosis showed localized bladder tumor, final histopathology revealed pT4, G3, L1 urothelial carcinoma with clear cell differentiation. No more than 14 weeks after initial diagnosis the patient died from multi-organ failure after unsuccessful salvage laparotomy which showed massive tumor burden within the pelvis and peritoneal carcinosis. This case demonstrated an extremely fast tumor growth. Therefore, patients with clear cell urothelial carcinoma should be treated vigorously and without time delay. We present a case of clear cell variant of TCC which exhibited an extremely aggressive behavior. To our knowledge this is the fifth report of this rare disease.

Original languageEnglish
JournalRare Tumors
Issue number4
Pages (from-to)153-155
Number of pages3
Publication statusPublished - 2012

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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