TY - JOUR
T1 - Layered double hydroxides as efficient drug delivery system of ciprofloxacin in the middle ear: An animal study in rabbits
AU - Hesse, Daniela
AU - Badar, Muhammad
AU - Bleich, André
AU - Smoczek, Anna
AU - Glage, Silke
AU - Kieke, Marc
AU - Behrens, Peter
AU - Müller, Peter Paul
AU - Esser, Karl Heinz
AU - Stieve, Martin
AU - Prenzler, Nils Kristian
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Chronic otitis media is a common disease often accompanied by recurrent bacterial infections. These may lead to the destruction of the middle ear bones such that prostheses have to be implanted to restore sound transmission. Surface coatings with layered double hydroxides (LDHs) are evaluated here as a possibility for drug delivery systems with convenient advantages such as low cytotoxicity and easy synthesis. Male New Zealand White rabbits were implanted with Bioverit® II middle ear prostheses coated with the LDH Mg 4Al2(OH)12(SO4)2· 6H2O impregnated with ciprofloxacin. 12 (group 1) were directly infected with Pseudomonas aeruginosa and another 12 (group 2) 1 week after the implantation. Clinical outcome, blood counts, histological analyses and microbiological examination showed an excellent antimicrobial activity for group 1, whereas this effect was attenuated in animals where infection was performed 1 week after implantation. This is the first study to demonstrate an efficient drug delivery system with an LDH coating on prostheses in the middle ear.
AB - Chronic otitis media is a common disease often accompanied by recurrent bacterial infections. These may lead to the destruction of the middle ear bones such that prostheses have to be implanted to restore sound transmission. Surface coatings with layered double hydroxides (LDHs) are evaluated here as a possibility for drug delivery systems with convenient advantages such as low cytotoxicity and easy synthesis. Male New Zealand White rabbits were implanted with Bioverit® II middle ear prostheses coated with the LDH Mg 4Al2(OH)12(SO4)2· 6H2O impregnated with ciprofloxacin. 12 (group 1) were directly infected with Pseudomonas aeruginosa and another 12 (group 2) 1 week after the implantation. Clinical outcome, blood counts, histological analyses and microbiological examination showed an excellent antimicrobial activity for group 1, whereas this effect was attenuated in animals where infection was performed 1 week after implantation. This is the first study to demonstrate an efficient drug delivery system with an LDH coating on prostheses in the middle ear.
UR - http://www.scopus.com/inward/record.url?scp=84872411272&partnerID=8YFLogxK
U2 - 10.1007/s10856-012-4769-1
DO - 10.1007/s10856-012-4769-1
M3 - Journal articles
C2 - 23053799
AN - SCOPUS:84872411272
SN - 0957-4530
VL - 24
SP - 129
EP - 136
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 1
ER -