Pulsed laser irradiation allows a selective photothermolysis by confining thermal damage to the absorbing structures. For example, laser pulses with micro- and millisecond duration are used for a selective targeting of blood vessels. However, at the moment it is not clear, whether also single cells, cell organelles or even macromolecules can be selectively destroyed by thermal laser effects. Therefore the temperature which can be achieved by laser irradiation of particles and absorbing spherical volumes with diameters ranging from 1 nm to 1 μm were calculated using Mie theory and an analytical solution of the equations for heat diffusion. The temperatures which are necessary for selective thermal effects in these small volumes were estimated by the Arrhenius equation. Calculations show that selective thermal effects with nanometer precision could be possible, if the Arrhenius equation is still valid on a time scale from micro- to picoseconds.
|Translated title of the contribution||Laser induced thermal tissue effects with microscopic and macromolecular precision?|
|Journal||Zeitschrift fur Medizinische Physik|
|Number of pages||6|
|Publication status||Published - 2000|
Research Areas and Centers
- Academic Focus: Biomedical Engineering