Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Bernd Schultes; Sebastian M. Schmid; Britta Wilms; Kamila Jauch-Chara; Kerstin M. Oltmanns; Manfred Hallschmid

doi:10.1016/j.appet.2012.01.022

Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Bernd Schultes^*, Sebastian M. Schmid, Britta Wilms, Kamila Jauch-Chara, Kerstin M. Oltmanns, Manfred Hallschmid

^*Corresponding author for this work

25 Citations (Scopus)

Abstract

Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m²) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.

Original language	English
Journal	Appetite
Volume	58
Issue number	3
Pages (from-to)	818-821
Number of pages	4
ISSN	0195-6663
DOIs	https://doi.org/10.1016/j.appet.2012.01.022
Publication status	Published - 01.06.2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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10.1016/j.appet.2012.01.022

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title = "Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men",

abstract = "Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.",

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T1 - Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

AU - Schultes, Bernd

AU - Schmid, Sebastian M.

AU - Wilms, Britta

AU - Jauch-Chara, Kamila

AU - Oltmanns, Kerstin M.

AU - Hallschmid, Manfred

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.

AB - Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.

UR - https://www.scopus.com/pages/publications/84857580283

U2 - 10.1016/j.appet.2012.01.022

DO - 10.1016/j.appet.2012.01.022

M3 - Journal articles

C2 - 22314041

AN - SCOPUS:84857580283

SN - 0195-6663

VL - 58

SP - 818

EP - 821

JO - Appetite

JF - Appetite

IS - 3

ER -

Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

Abstract

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