TY - JOUR
T1 - Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men
AU - Schultes, Bernd
AU - Schmid, Sebastian M.
AU - Wilms, Britta
AU - Jauch-Chara, Kamila
AU - Oltmanns, Kerstin M.
AU - Hallschmid, Manfred
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.
AB - Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40years; BMI: 20-26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.
UR - http://www.scopus.com/inward/record.url?scp=84857580283&partnerID=8YFLogxK
U2 - 10.1016/j.appet.2012.01.022
DO - 10.1016/j.appet.2012.01.022
M3 - Journal articles
C2 - 22314041
AN - SCOPUS:84857580283
SN - 0195-6663
VL - 58
SP - 818
EP - 821
JO - Appetite
JF - Appetite
IS - 3
ER -
