Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation

Daphne Shimron-Abarbanell; Markus M. Nöthen; Jeanette Erdmann; Peter Propping

doi:10.1016/0169-328X(95)00003-B

Lack of genetically determined structural variants of the human serotonin-1E (5-HT_1E) receptor protein points to its evolutionary conservation

Daphne Shimron-Abarbanell, Markus M. Nöthen^*, Jeanette Erdmann, Peter Propping

^*Corresponding author for this work

Institute of Cardiogenetics

University of Bonn

25 Citations (Scopus)

Abstract

Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT_1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT_1E receptor protein points to a high evolutionary conservation of this receptor protein.

Original language	English
Journal	Molecular Brain Research
Volume	29
Issue number	2
Pages (from-to)	387-390
Number of pages	4
ISSN	0169-328X
DOIs	https://doi.org/10.1016/0169-328X(95)00003-B
Publication status	Published - 01.01.1995

Funding

This work was supported by the Deutsche Forschungsgemeinschaft. We thank Dres. M. Ri-etschel, J. K6rner, J. Hebebrand, K. Hebebrand, R. Wettke-Sch~ifer, S. Lisch, A. von Gontard, G. Lehmkuhl, M. Schmidt, F. Poustka and H. Rem-schmidt for contribution of patients to the study.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 5 Gender Equality

Access to Document

10.1016/0169-328X(95)00003-B

Cite this

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title = "Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation",

abstract = "Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.",

author = "Daphne Shimron-Abarbanell and N{\"o}then, \{Markus M.\} and Jeanette Erdmann and Peter Propping",

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journal = "Molecular Brain Research",

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Lack of genetically determined structural variants of the human serotonin-1E (5-HT_1E) receptor protein points to its evolutionary conservation. / Shimron-Abarbanell, Daphne; Nöthen, Markus M.; Erdmann, Jeanette et al.
In: Molecular Brain Research, Vol. 29, No. 2, 01.01.1995, p. 387-390.

Research output: Journal Articles › Journal articles › Research › peer-review

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T1 - Lack of genetically determined structural variants of the human serotonin-1E (5-HT1E) receptor protein points to its evolutionary conservation

AU - Shimron-Abarbanell, Daphne

AU - Nöthen, Markus M.

AU - Erdmann, Jeanette

AU - Propping, Peter

PY - 1995/1/1

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N2 - Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.

AB - Using single strand conformational analysis, we screened the complete coding sequence of the serotonin-lE (5-HT1E) receptor gene for the presence of DNA sequence variation in a sample of 157 unrelated individuals. We detected only a silent C → T transition at the third position of codon 177. The lack of significant mutations leading to structural variants of the human 5-HT1E receptor protein points to a high evolutionary conservation of this receptor protein.

UR - https://www.scopus.com/pages/publications/0028937303

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DO - 10.1016/0169-328X(95)00003-B

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SN - 0169-328X

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EP - 390

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JF - Molecular Brain Research

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