Lack of expression of interleukin 8 and RANTES in autoimmune bullous skin diseases

Erika Bornscheuer*, D. Zillikens, J. M. Schröder, M. Sticherling

*Corresponding author for this work
13 Citations (Scopus)


Background: In autoimmune bullous skin diseases, accumulation of neutrophils and/or eosinophils in the affected skin represents a characteristic feature. So far, however, the induction of this granulocyte infiltration has not been elucidated. Objective: Regarding their biological effects, the chemokines interleukin 8 (IL-8) and RANTES (regulated upon activation normal T lymphocyte expressed and secreted) could play a role in this granulocyte accumulation. Methods: Immunohistochemical examination of lesional skin from patients with bullous pemphigoid, pemphigus, dermatitis herpetiformis and linear IgA disease was performed using a set of different antibodies against IL-8 and RANTES. Additionally, blister fluids were screened for soluble RANTES peptide using an ELISA. Results: No difference in chemokine expression was found in lesions of autoimmune bullous diseases compared to normal skin. Conclusion: In contrast to chronic inflammatory diseases like psoriasis and eczema, where keratinocyte IL-8 immunoreactivity was found to differ from normal skin, keratinocyte immunoreactivity is not altered in autoimmune bullous diseases.

Original languageEnglish
Issue number2
Pages (from-to)118-121
Number of pages4
Publication statusPublished - 1999


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