TY - JOUR
T1 - Lack of evidence for Marek's disease virus genomic sequences in leukocyte DNA from multiple sclerosis patients in Germany
AU - Hennig, Holger
AU - Wessel, Karl
AU - Sondermeijer, Paul
AU - Kirchner, Holger
AU - Wandinger, Klaus P.
PY - 1998/6/19
Y1 - 1998/6/19
N2 - Herpes viruses have repeatedly been associated with the etiology of multiple sclerosis (MS). In the course of investigations on a cluster of MS patients in Key West, Florida, it was suggested that Marek's disease virus (MDV), a cell-associated avian herpes virus, might be involved in the pathogenesis of the disease. The aim of our study was to investigate 107 well-defined MS patients with regard to latent MDV infection. Using a highly- sensitive polymerase chain reaction technique, we did not find MDV-related sequences in leukocyte DNA of any of the patients. The results of our study do not suggest an implication of MDV in the pathogenesis of MS.
AB - Herpes viruses have repeatedly been associated with the etiology of multiple sclerosis (MS). In the course of investigations on a cluster of MS patients in Key West, Florida, it was suggested that Marek's disease virus (MDV), a cell-associated avian herpes virus, might be involved in the pathogenesis of the disease. The aim of our study was to investigate 107 well-defined MS patients with regard to latent MDV infection. Using a highly- sensitive polymerase chain reaction technique, we did not find MDV-related sequences in leukocyte DNA of any of the patients. The results of our study do not suggest an implication of MDV in the pathogenesis of MS.
UR - http://www.scopus.com/inward/record.url?scp=0344073982&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(98)00445-5
DO - 10.1016/S0304-3940(98)00445-5
M3 - Journal articles
C2 - 9697938
AN - SCOPUS:0344073982
SN - 0304-3940
VL - 250
SP - 138
EP - 140
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -
