Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder

M M Nöthen; J Erdmann; J Körner; M Lanczik; J Fritze; R Fimmers; D K Grandy; B O'Dowd; P Propping

doi:10.1176/ajp.149.2.199

Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder

M M Nöthen, J Erdmann, J Körner, M Lanczik, J Fritze, R Fimmers, D K Grandy, B O'Dowd, P Propping

Institute of Cardiogenetics

University of Bonn

68 Citations (Scopus)

Abstract

Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.

Original language	English
Journal	The American journal of psychiatry
Volume	149
Issue number	2
Pages (from-to)	199-201
Number of pages	3
ISSN	0002-953X
DOIs	https://doi.org/10.1176/ajp.149.2.199
Publication status	Published - 02.1992

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10.1176/ajp.149.2.199

Cite this

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abstract = "Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.",

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AU - Nöthen, M M

AU - Erdmann, J

AU - Körner, J

AU - Lanczik, M

AU - Fritze, J

AU - Fimmers, R

AU - Grandy, D K

AU - O'Dowd, B

AU - Propping, P

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AB - Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.

U2 - 10.1176/ajp.149.2.199

DO - 10.1176/ajp.149.2.199

M3 - Journal articles

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SN - 0002-953X

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JF - The American journal of psychiatry

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