TY - JOUR
T1 - Lässt sich die Expression von EZM-Proteinen durch Kompression beeinflussen?
AU - Gerdes, Okka
AU - Brinckmann, J.
AU - Zillikens, D.
AU - Kahle, B.
PY - 2012/9/13
Y1 - 2012/9/13
N2 - Background: The advanced states of the chronic venous insufficiency (CVI) are characterized by an increased protein expression of tenascin C, fibrillin 2 and α-smooth muscle actin. These proteins of the extracellular maktrix are augmentedly expressed during wound healing in hypertrophy scars. Objective: Is the expression of the proteins tenascin C, fibrillin2 und α-smooth muscle actin suggestible by compression? Patient and Methods: We investigated the skin of 23 patients (12 in state C2 and 11 in state C4). These patients were not treated with compression therapy before. They got compression stockings for 2 or 4 weeks (VenoTrain delight or VenoTrain micro). On day 1, 14 and 28 we took a skin sample from the ankle.Results: In stadium C2 of the CVI there was an expression as in normal skin, a small band belong the dermal-epidermal junction and in blood vessels. In stadium C4 the expression varied corresponding to the clinical figure. In lipodermatosclerosis, tenascin C and fibrillin 2 were increasingly expressed in the whole dermis. On hyperpigmentation or in stasis dermatitis there was an increased expression just in a few biopsies. In some cases the augmented expression was present in the deeper dermis, in other cases in the dermal-epidermal junction. α-smooth muscle actin was expressed in both stadium C2 and C4 only in blood vessels. Druing the study an effect of compression therapy on protein expression was not obvious. Conclusion: Tenascin C and fibrillin 2 were only expressed in the state of a sclerosis. The influence of compression on the expression of extracellular matrix proteins needs further investigations.
AB - Background: The advanced states of the chronic venous insufficiency (CVI) are characterized by an increased protein expression of tenascin C, fibrillin 2 and α-smooth muscle actin. These proteins of the extracellular maktrix are augmentedly expressed during wound healing in hypertrophy scars. Objective: Is the expression of the proteins tenascin C, fibrillin2 und α-smooth muscle actin suggestible by compression? Patient and Methods: We investigated the skin of 23 patients (12 in state C2 and 11 in state C4). These patients were not treated with compression therapy before. They got compression stockings for 2 or 4 weeks (VenoTrain delight or VenoTrain micro). On day 1, 14 and 28 we took a skin sample from the ankle.Results: In stadium C2 of the CVI there was an expression as in normal skin, a small band belong the dermal-epidermal junction and in blood vessels. In stadium C4 the expression varied corresponding to the clinical figure. In lipodermatosclerosis, tenascin C and fibrillin 2 were increasingly expressed in the whole dermis. On hyperpigmentation or in stasis dermatitis there was an increased expression just in a few biopsies. In some cases the augmented expression was present in the deeper dermis, in other cases in the dermal-epidermal junction. α-smooth muscle actin was expressed in both stadium C2 and C4 only in blood vessels. Druing the study an effect of compression therapy on protein expression was not obvious. Conclusion: Tenascin C and fibrillin 2 were only expressed in the state of a sclerosis. The influence of compression on the expression of extracellular matrix proteins needs further investigations.
UR - https://www.scopus.com/pages/publications/84865998523
M3 - Zeitschriftenaufsätze
AN - SCOPUS:84865998523
SN - 0939-978X
VL - 41
SP - 121
EP - 127
JO - Phlebologie
JF - Phlebologie
IS - 3
ER -
SDG 3 Good Health and Well-being