KATP-dependent neurotransmitter release in the neuronal network of the rat caudate nucleus

Mirja Steinkamp; Tianlang Li; Henriette Fuellgraf; Andreas Moser

doi:10.1016/j.neuint.2006.07.011

K_ATP-dependent neurotransmitter release in the neuronal network of the rat caudate nucleus

Mirja Steinkamp, Tianlang Li, Henriette Fuellgraf, Andreas Moser^*

^*Corresponding author for this work

Clinic of Neurology

Zhejiang University

9 Citations (Scopus)

Abstract

K_ATP channels can couple the bioenergetic metabolism of the cell to membrane excitability. Here, we show γ-aminobutyric acid (GABA) mediated inhibition of dopamine outflow from slices of the rat caudate nucleus that is regulated by extracellular glucose via high- and low-affinity K_ATP channels. During glucose reduction, a biphasic dopamine effect could be observed with first a dopamine increase followed by a decline at low glucose concentrations. Both phases were inhibited by glibenclamide. Pinacidil decreased DA outflow without an effect of glucose reduction implying an overall activation of K_ATP channels. The first phase with dopamine increase was related to reduced GABAergic activity and could be blocked by bicuculline. Our results may be explained by different types of K_ATP channels with low affinity of ATP and glibenclamide on inhibitory GABAergic and high-affinity on excitatory DAergic neurons. This led us to suggest a biological principle through which neuronal networks are functioning.

Original language	English
Journal	Neurochemistry International
Volume	50
Issue number	1
Pages (from-to)	159-163
Number of pages	5
ISSN	0197-0186
DOIs	https://doi.org/10.1016/j.neuint.2006.07.011
Publication status	Published - 01.01.2007

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neuint.2006.07.011

Cite this

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abstract = "KATP channels can couple the bioenergetic metabolism of the cell to membrane excitability. Here, we show γ-aminobutyric acid (GABA) mediated inhibition of dopamine outflow from slices of the rat caudate nucleus that is regulated by extracellular glucose via high- and low-affinity KATP channels. During glucose reduction, a biphasic dopamine effect could be observed with first a dopamine increase followed by a decline at low glucose concentrations. Both phases were inhibited by glibenclamide. Pinacidil decreased DA outflow without an effect of glucose reduction implying an overall activation of KATP channels. The first phase with dopamine increase was related to reduced GABAergic activity and could be blocked by bicuculline. Our results may be explained by different types of KATP channels with low affinity of ATP and glibenclamide on inhibitory GABAergic and high-affinity on excitatory DAergic neurons. This led us to suggest a biological principle through which neuronal networks are functioning.",

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