Krebsrisiko nach ovarieller simulation

The issue of whether hormonal ovarian stimulation increases the risk of gynecological cancers continues to be controversial. Some studies have suggested that there are risk factors among infertile women that lead to an increased risk of certain malignant tumors. These include nulligravidity, long stimulation treatments in patients with a long follow-up, and frequent stimulation cycles using clomiphene. In addition, there appears to be a slight increase in the incidence of borderline tumors during ovarian stimulation. The results on breast cancer differ widely between the studies, while more recent studies on endometrial cancers indicate an increased risk of disease after stimulation using clomiphene. The results of the individuals studies need to be further investigated, particularly as the patients who have undergone ovarian stimulation are only just reaching the malignancy-specific age peak for cancer. Further epidemiological studies need to be conducted and data obtained from longer follow-up periods in ongoing studies to be able to answer this question more confidently.