Kontroversen in der Reproduktionsmedizin: Kontroversen und Sachstand zu Metformin bei PCOS, Assisted Hatching, Aneuploidiescreening, Blastozystenkultur und Aneuploidiescreening

Despite substantial scientific and clinical efforts, in vitro fertilization (IVF) per treatment cycle is still relatively unsuccessful over the last 3 decades and the pregnancy rate per transfer is less than 30%. In this article the various approaches to increase the efficiency of IVF procedures will be presented and discussed as well as the use of metformin for polycystic ovarian syndrome (PCOS), assisted hatching using various methods, aneuploidy screening of oocytes and embryos, blastocyst transfer and adjuvant acupuncture. Under the criteria of evidence-based medicine meta-analyses and when available also Cochcrane analyses are reported and critically discussed.