Kombiniertes auftreten von amyotropher lateralsklerose und multipler sklerose

Translated title of the contribution: Simultaneous presentation of amyotrophic lateral sclerosis and multiple sclerosis

B. Machner*, S. Gottschalk, H. Kimmig, C. Helmchen

*Corresponding author for this work
4 Citations (Scopus)


The concurrence of amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is extremely rare. We report on a 55-year-old female patient presenting with a progressive gait disorder for 6 months and a speech disorder for 3 months. Neurological examination revealed a spastic paraparesis and mild dysarthria and dysphagia. Technical and laboratory investigations met the diagnostic criteria for MS: magnetic resonance imaging showed multiple periventricular white matter and cervical lesions; cerebrospinal fluid showed a typical autoimmune response. Within the following 3 months generalized fasciculations, atrophy of the small hand muscles and bulbar signs were noticed. Nerve conduction studies revealed acute and chronic signs of denervation in all limbs without nerve conduction block. Hence clinical and paraclinical examination met the El Escorial criteria for ALS. Although myelitic lesions in the anterior horn cells may lead to peripheral segmental denervation, the generalized denervation suggested the unusual coincident combination of ALS and MS in this patient. In clinical praxis motoneuron diseases should also be considered in patients with pronounced peripheral denervations once "definite" MS has been diagnosed.

Translated title of the contributionSimultaneous presentation of amyotrophic lateral sclerosis and multiple sclerosis
Original languageGerman
Issue number12
Pages (from-to)1440-1443
Number of pages4
Publication statusPublished - 01.12.2007

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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